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anti-SLC22A12 antibody :: Rabbit anti-Human SLC22A12 Polyclonal Antibody

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Catalog # MBS2529149
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

SLC22A12, Polyclonal Antibody

Popular Item
Full Product Name

SLC22A12 Polyclonal Antibody

Product Synonym Names
RST; OAT4L; URAT1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
220150
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Concentration
0.3mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SLC22A12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC22A12 antibody
Background/Introduction: The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
Applications Tested/Suitable for anti-SLC22A12 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SLC22A12 antibody
WB: 1:200-1:1000
IHC: 1:25-1:100

Western Blot (WB) of anti-SLC22A12 antibody
Western Blot analysis of Hela and 293T cell using SLC22A12 Polyclonal Antibody at dilution of 1:200
anti-SLC22A12 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SLC22A12 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer using SLC22A12 Polyclonal Antibody at dilution of 1:20
anti-SLC22A12 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SLC22A12 antibody
Immunohistochemistry of paraffin-embedded Human brain using SLC22A12 Polyclonal Antibody at dilution of 1:20
anti-SLC22A12 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SLC22A12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
solute carrier family 22 member 12 isoform d
NCBI Official Synonym Full Names
solute carrier family 22 (organic anion/urate transporter), member 12
NCBI Official Symbol
SLC22A12  [Similar Products]
NCBI Official Synonym Symbols
RST; OAT4L; URAT1
  [Similar Products]
NCBI Protein Information
solute carrier family 22 member 12; organic anion transporter 4-like protein; renal-specific transporter; solute carrier family 22 (organic anion/cation transporter), member 12; urate anion exchanger 1; urate transporter 1
UniProt Protein Name
Solute carrier family 22 member 12
UniProt Synonym Protein Names
Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1
Protein Family
UniProt Gene Name
SLC22A12  [Similar Products]
UniProt Synonym Gene Names
OATL4; URAT1; RST  [Similar Products]
UniProt Entry Name
S22AC_HUMAN
NCBI Summary for SLC22A12
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for SLC22A12
SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: urate transmembrane transporter activity; PDZ domain binding

Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport

Disease: Hypouricemia, Renal, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-SLC22A12 antibody
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