NP_653186
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
solute carrier family 22 member 12 isoform d
NCBI Official Synonym Full Names
solute carrier family 22 (organic anion/urate transporter), member 12
NCBI Protein Information
solute carrier family 22 member 12; organic anion transporter 4-like protein; renal-specific transporter; solute carrier family 22 (organic anion/cation transporter), member 12; urate anion exchanger 1; urate transporter 1
UniProt Protein Name
Solute carrier family 22 member 12
UniProt Synonym Protein Names
Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1
UniProt Synonym Gene Names
UniProt Entry Name
S22AC_HUMAN
NCBI Summary for SLC22A12
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for SLC22A12
SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: urate transmembrane transporter activity; PDZ domain binding
Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport
Disease: Hypouricemia, Renal, 1
Research Articles on SLC22A12
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-SLC22A12 antibody
Pathways associated with anti-SLC22A12 antibody
Diseases associated with anti-SLC22A12 antibody
Organs/Tissues associated with anti-SLC22A12 antibody
|