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anti-SLC26A2 antibody :: Rabbit anti-Human SLC26A2 Polyclonal Antibody

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Catalog # MBS9125127
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Immunofluorescence (IF)
Product Name

SLC26A2, Polyclonal Antibody

Full Product Name

SLC26A2 Polyclonal Antibody

Product Synonym Names
DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 606718
3D Structure
ModBase 3D Structure for P50443
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Species
Human
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human SLC26A2
Calculated Molecular Weight
81kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-SLC26A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC26A2 antibody
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization.
Product Categories/Family for anti-SLC26A2 antibody
Applications Tested/Suitable for anti-SLC26A2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SLC26A2 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:100

Immunofluorescence (IF) of anti-SLC26A2 antibody
Immunofluorescence analysis of HeLa cells using SLC26A2 antibody. Blue: DAPI for nuclear staining.
anti-SLC26A2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SLC26A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
739
NCBI Official Full Name
Sulfate transporter
NCBI Official Synonym Full Names
solute carrier family 26 (anion exchanger), member 2
NCBI Official Symbol
SLC26A2  [Similar Products]
NCBI Official Synonym Symbols
DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
  [Similar Products]
NCBI Protein Information
sulfate transporter; sulfate anion transporter 1; diastrophic dysplasia protein; solute carrier family 26 (sulfate transporter), member 2
UniProt Protein Name
Sulfate transporter
UniProt Synonym Protein Names
Diastrophic dysplasia protein; Solute carrier family 26 member 2
Protein Family
UniProt Gene Name
SLC26A2  [Similar Products]
UniProt Synonym Gene Names
DTD; DTDST  [Similar Products]
UniProt Entry Name
S26A2_HUMAN
NCBI Summary for SLC26A2
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC26A2
SLC26A2: Sulfate transporter. May play a role in endochondral bone formation. Defects in SLC26A2 are the cause of diastrophic dysplasia (DTD). DTD is an autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. Defects in SLC26A2 are the cause of achondrogenesis type 1B (ACG1B). ACG1B is a recessively inherited chondrodysplasia characterized by extremely poor skeletal development and perinatal death. Defects in SLC26A2 are the cause of atelosteogenesis type 2 (AO2); also known as neonatal osseous dysplasia 1. AO2 is characterized by severely shortened limbs, small chest, scoliosis, club foot of the equinovarus type (talipes equinovarus), abducted thumbs and great toes, and cleft palate. Patients die of respiratory insufficiency shortly after birth because of the collapse of the airways and pulmonary hypoplasia due to the small rib cage. Defects in SLC26A2 are the cause of multiple epiphyseal dysplasia type 4 (EDM4). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature in EDM4 patients is not frequent. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31-q34

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity

Biological Process: ossification; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; sulfate transport; ion transport; pathogenesis; transmembrane transport; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

Disease: Atelosteogenesis, Type Ii; Diastrophic Dysplasia; Achondrogenesis, Type Ib; Epiphyseal Dysplasia, Multiple, 4
Precautions
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Disclaimer
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