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anti-SLC35D2 antibody :: Rabbit anti-Human SLC35D2 Polyclonal Antibody

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Catalog # MBS151008
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

SLC35D2, Polyclonal Antibody

Popular Item
Full Product Name

SLC35D2 Antibody

Product Synonym Names
SLC35D2; hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; Homolog of Fringe connection protein 1; solute carrier family 35, member D2
Antibody/Peptide Pairs
SLC35D2 peptide (MBS152870) is used for blocking the activity of SLC35D2 antibody (MBS151008)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q76EJ3
Species Reactivity
At least two isoforms of SLC35D2 are known to exist; this antibody will recognize both isoforms. SLC35D2 antibody is predicted to not cross-react with SLC35D1 or SLC35D3.
SLC35D2 Antibody is affinity chromatography purified via peptide column.
1 mg/mL (lot specific)
SLC35D2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human SLC35D2.
SLC35D2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SLC35D2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-SLC35D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC35D2 antibody
SLC35D2 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.
Applications Tested/Suitable for anti-SLC35D2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-SLC35D2 antibody
SLC35D2 antibody can be used for detection of SLC35D2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-SLC35D2 antibody
Western blot analysis of SLC35D2 in HeLa cell lysate with SLC35D2 antibody at (A) 1 and (B) 2 μg/mL.
anti-SLC35D2 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-SLC35D2 antibody
Immunocytochemistry of SLC35D2 in HeLa cells with SLC35D2 antibody at 5 μg/mL.
anti-SLC35D2 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for SLC35D2. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,702 Da
NCBI Official Full Name
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a
NCBI Official Synonym Full Names
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
NCBI Official Symbol
SLC35D2  [Similar Products]
NCBI Official Synonym Symbols
hfrc; HFRC1; SQV7L; UGTrel8
  [Similar Products]
NCBI Protein Information
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8
UniProt Protein Name
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
UniProt Synonym Protein Names
Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8
UniProt Gene Name
SLC35D2  [Similar Products]
UniProt Synonym Gene Names
HFRC; UGTREL8; HFRC1; SQV7L; UGTrel8  [Similar Products]
UniProt Entry Name
NCBI Summary for SLC35D2
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
UniProt Comments for SLC35D2
SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q22.32

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: nucleotide-sugar transmembrane transporter activity

Biological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate transport; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; transmembrane transport
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Products associated withanti-SLC35D2 antibody
 Reference Product  PubMed Publications
 SLC35F4 antibody  >1 publications with SLC35D2 and SLC35F4
Diseases associated with anti-SLC35D2 antibody
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