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anti-SOSS antibody :: Rabbit anti-Human SOSS complex subunit B2 Polyclonal Antibody

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Catalog # MBS1492553
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Western Blot (WB)
Product Name

SOSS complex subunit B2, Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human SOSS complex subunit B2 polyclonal Antibody

Product Synonym Names
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2; NABP1; OBFC2A; SSB2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
204
OMIM
612103
3D Structure
ModBase 3D Structure for Q96AH0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human SOSS complex subunit B2 protein(1-204aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168821
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SOSS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOSS antibody
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Applications Tested/Suitable for anti-SOSS antibody
ELISA (EIA), Western Blot (WB)

Western Blot (WB) of anti-SOSS antibody
Western blot
All lanes: SOSS complex subunit B2 antibody at 2ug/ml
Lane 1:Hela whole cell lysate
Lane 2:jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 23,14,15 kDa
Observed band size: 22 kDa

anti-SOSS antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SOSS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,677 Da
NCBI Official Full Name
SOSS complex subunit B2 isoform 1
NCBI Official Synonym Full Names
nucleic acid binding protein 1
NCBI Official Symbol
NABP1  [Similar Products]
NCBI Official Synonym Symbols
SSB2; OBFC2A; SOSS-B2
  [Similar Products]
NCBI Protein Information
SOSS complex subunit B2
UniProt Protein Name
SOSS complex subunit B2
UniProt Synonym Protein Names
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
Protein Family
UniProt Gene Name
NABP1  [Similar Products]
UniProt Synonym Gene Names
OBFC2A; SSB2; SOSS-B2; hSSB2  [Similar Products]
UniProt Entry Name
SOSB2_HUMAN
NCBI Summary for SOSS
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
UniProt Comments for SOSS
OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: protein binding; RNA binding; single-stranded DNA binding

Biological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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