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anti-SOX2 antibody :: Rabbit anti-Human SOX2 Polyclonal Antibody

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Catalog # MBS241751
Unit / Price
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  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

SOX2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human SOX2

Product Synonym Names
Anti-SOX2 Antibody (N-Terminus) IHC-plus; SOX2; MCOPS3; Transcription factor SOX2; ANOP3; Transcription factor SOX-2; SRY-related HMG-box gene 2; Human SOX2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 206900
3D Structure
ModBase 3D Structure for P48431
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Peptide-KLH (N-terminal)
Purity/Purification
Immunoaffinity Purified
Form/Format
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Concentration
0.25 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human SOX2.
Immunogen Type
Synthetic peptide
Immunogen
SOX2 antibody was raised against synthetic peptide from human SOX2.
Antigen Modification
N-Terminus
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-SOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX2 antibody
SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.
Product Categories/Family for anti-SOX2 antibody
Applications Tested/Suitable for anti-SOX2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-SOX2 antibody
IHC-P (1:50), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SOX2 antibody
Anti-SOX2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-SOX2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-SOX2 antibody
NTERA-2 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal antibody raised against the N-terminal region of SOX2. Proteins were visualized using HRP Donkey anti-rabbit IgG and a chemiluminescence detection system.
anti-SOX2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SOX2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,310 Da
NCBI Official Full Name
transcription factor SOX-2
NCBI Official Synonym Full Names
SRY (sex determining region Y)-box 2
NCBI Official Symbol
NCBI Official Synonym Symbols
ANOP3; MCOPS3
  [Similar Products]
NCBI Protein Information
transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2
UniProt Protein Name
Transcription factor SOX-2
UniProt Gene Name
UniProt Entry Name
SOX2_HUMAN
NCBI Summary for SOX2
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
UniProt Comments for SOX2
SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

Protein type: Cell development/differentiation; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 3q26.3-q27

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; olfactory placode formation; forebrain neuron differentiation; detection of mechanical stimulus involved in equilibrioception; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; tissue regeneration; forebrain development; male genitalia development; positive regulation of cell-cell adhesion; response to wounding; adenohypophysis development; positive regulation of epithelial cell differentiation; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; regulation of gene expression; pituitary gland development; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; pigment biosynthetic process; positive regulation of neuron differentiation; alveolus development; retina morphogenesis in camera-type eye

Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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