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anti-SRD5A1 antibody :: Goat SRD5A1/5-alpha reductase 1 Polyclonal Antibody

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Catalog # MBS420692
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

SRD5A1/5-alpha reductase 1, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-SRD5A1/5-alpha reductase 1 Antibody

Product Synonym Names
Goat Anti-SRD5A1 Antibody; SRD5A1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); 5-alpha reductase; steroid 5-alpha-reductase type I; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1; steroid-5-alpha-reductase 1; SRD5A1 antibody; steroid-5-alpha-reductase; alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) antibody; 5-alpha reductase antibody; steroid 5-alpha-reductase type I antibody; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 antibody; steroid-5-alpha-reductase 1 antibody; 5-alpha reductase 1; SRD5A1 / 5-alpha reductase 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
ATATGVAEER LLC
OMIM
184753
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence ATATGVAEERLLC, from the N Terminus of the protein sequence according to NP_001038.1.
Epitope
N Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-SRD5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SRD5A1 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SRD5A1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Prostate shows reticulate staining in the cytoplasm of secretory cells in the gland. Recommended concentration, 4-6ug/ml.

Immunohistochemistry (IHC) of anti-SRD5A1 antibody
(4ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
anti-SRD5A1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SRD5A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,459 Da
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 1
NCBI Official Synonym Full Names
steroid 5 alpha-reductase 1
NCBI Official Symbol
SRD5A1  [Similar Products]
NCBI Official Synonym Symbols
S5AR 1
  [Similar Products]
NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Synonym Protein Names
SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
UniProt Gene Name
SRD5A1  [Similar Products]
UniProt Synonym Gene Names
S5AR 1  [Similar Products]
UniProt Entry Name
S5A1_HUMAN
NCBI Summary for SRD5A1
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
UniProt Comments for SRD5A1
SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Belongs to the steroid 5-alpha reductase family.

Protein type: Membrane protein, integral; EC 1.3.1.22; Membrane protein, multi-pass; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane; myelin sheath; perinuclear region of cytoplasm

Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; electron carrier activity

Biological Process: androgen biosynthetic process; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; cerebral cortex development; circadian sleep/wake cycle, REM sleep; diterpenoid metabolic process; female genitalia development; hippocampus development; hypothalamus development; liver development; male genitalia development; male gonad development; pituitary gland development; progesterone metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to muscle activity; serotonin metabolic process; sex determination; spinal cord development; thalamus development; urogenital system development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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