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anti-SSTR2 antibody :: Rabbit anti-Human SSTR2 Polyclonal Antibody

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Catalog # MBS7046095
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

SSTR2, Polyclonal Antibody

Popular Item
Full Product Name

SSTR2 Antibody

Product Synonym Names
Somatostatin receptor type 2; SS-2-R; SS2-R; SS2R; SRIF-1; SSTR2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
182452
3D Structure
ModBase 3D Structure for P30874
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Somatostatin receptor type 2 protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11608 / sc-11606 / sc-11609 / sc-25676
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SSTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SSTR2 antibody
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Applications Tested/Suitable for anti-SSTR2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western Blot (WB) of anti-SSTR2 antibody
Western Blot
Positive WB detected in:mouse spleen tissue
All lanes: SSTR2 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42,41 kDa
Observed band size: 41 kDa

anti-SSTR2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SSTR2 antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7046095 at dilution of 1:100
anti-SSTR2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-SSTR2 antibody
Immunofluorescent analysis of HepG2 cells using MBS7046095 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SSTR2 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-SSTR2 antibody
Immunofluorescent analysis of PC3 cells cells using MBS7046095 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SSTR2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SSTR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,007 Da
NCBI Official Full Name
somatostatin receptor type 2
NCBI Official Synonym Full Names
somatostatin receptor 2
NCBI Official Symbol
SSTR2  [Similar Products]
NCBI Protein Information
somatostatin receptor type 2
UniProt Protein Name
Somatostatin receptor type 2
UniProt Synonym Protein Names
SRIF-1
Protein Family
UniProt Gene Name
SSTR2  [Similar Products]
UniProt Synonym Gene Names
SS-2-R; SS2-R; SS2R  [Similar Products]
UniProt Entry Name
SSR2_HUMAN
NCBI Summary for SSTR2
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
UniProt Comments for SSTR2
SSTR2: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. The C-terminus interacts with SHANK1 PDZ domain. Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide binding; PDZ domain binding; protein binding

Biological Process: cell-cell signaling; digestion; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; response to nutrient; synaptic transmission
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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