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anti-Stat antibody :: Rabbit anti-Human STAT 2, phosphorlated Polyclonal Antibody

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Catalog # MBS614758
Unit / Price
  0.05 mg  /  $670 +1 FREE 8GB USB
anti-Stat antibody
Product Name

STAT 2, phosphorlated, Polyclonal Antibody

Full Product Name

STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)

Product Synonym Names
Anti -STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7QDU4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human phospho-STAT2 (Tyr689).
Purity/Purification
Affinity Purified
Purified by immunoaffinity and Protein A affinity chromatography.
Form/Format
Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitution: Reconstitute with sterile PBS, 0.02% sodium azide.
Immunogen
Phosphopeptide containing Y689 site of human STAT2
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-Stat antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Stat antibody
STAT2 (signal transducer and activator of transcription #2) is a 98kD member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is associated with type I (and --) interferon signaling. All STATs contain an N-terminal oligomerization domain, a DNA-binding domain, and an SH2-association region. STAT2 is phosphorylated at Y689 by receptor-associated Janus kinases (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.
Applications Tested/Suitable for anti-Stat antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-Stat antibody
Western Blot, Flow Cytometry
Dilution: Western Blot: 0.5ug/ml
NCBI/Uniprot data below describe general gene information for Stat. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
83,879 Da[Similar Products]
NCBI Official Full Name
stat
UniProt Protein Name
Signal transducer and transcription activator
UniProt Synonym Protein Names
Ag-STAT
UniProt Gene Name
UniProt Entry Name
STAT_ANOGA
UniProt Comments for Stat
Function: Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression

By similarity. The STAT pathway directly participates in immune responses in insects. Ref.1

Subunit structure: Forms a homodimer or a heterodimer with a related family member

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Note: Translocated into the nucleus in response to phosphorylation

By similarity.

Tissue specificity: Expressed in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells. Ref.1

Developmental stage: Expressed at all developmental stages. Ref.1

Induction: Bacterial challenge results in nuclear translocation in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates protein to the nucleus in midgut epithelial cells. Ref.1

Sequence similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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