NP_001193793.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,219 Da
NCBI Official Full Name
STE20-related kinase adapter protein beta isoform 2
NCBI Official Synonym Full Names
STE20-related kinase adaptor beta
NCBI Official Synonym Symbols
PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038 [Similar Products]
NCBI Protein Information
STE20-related kinase adapter protein beta
UniProt Protein Name
STE20-related kinase adapter protein beta
UniProt Synonym Protein Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2
UniProt Synonym Gene Names
UniProt Entry Name
STRAB_HUMAN
NCBI Summary for STRADB
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
UniProt Comments for STRADB
STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; Motility/polarity/chemotaxis; STE group; STE20 family; STLK subfamily
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; MAP kinase kinase kinase activity; protein binding; protein kinase activity
Biological Process: activation of MAPKK activity; activation of protein kinase activity; cell cycle arrest; cell morphogenesis; insulin receptor signaling pathway; MAPKKK cascade; protein amino acid phosphorylation; protein export from nucleus; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway
Research Articles on STRADB
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Pathways associated with anti-STRADB antibody
Organs/Tissues associated with anti-STRADB antibody
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