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anti-TERF1 antibody :: Rabbit anti-Human TERF1 Polyclonal Antibody

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Catalog # MBS1496917
Unit / Price
Scan QR to view Datasheet
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

TERF1, Polyclonal Antibody

Popular Item
Full Product Name

TERF1 Antibody

Product Synonym Names
NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1; TERF1; PIN2; TRBF1; TRF; TRF1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600951
3D Structure
ModBase 3D Structure for P54274
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Telomeric repeat-binding factor 1 protein (260-439aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1977 / sc-5596 / sc-6165-R
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TERF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TERF1 antibody
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Applications Tested/Suitable for anti-TERF1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TERF1 antibody
Recommended dilution: WB:1:200-1000
IHC:1:20-1:200

Western Blot (WB) of anti-TERF1 antibody
Western blot
All lanes: TERF1 antibody at 2ug/ml
Lane 1:k562 whole cell lysate
Lane 2:293T whole cell lysate
Lane 3:Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 51,49 kDa
Observed band size: 50 kDa

anti-TERF1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TERF1 antibody
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS1496917 at dilution 1:100
anti-TERF1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TERF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,239 Da
NCBI Official Full Name
telomeric repeat-binding factor 1 isoform 2
NCBI Official Synonym Full Names
telomeric repeat binding factor (NIMA-interacting) 1
NCBI Official Symbol
TERF1  [Similar Products]
NCBI Official Synonym Symbols
TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS
  [Similar Products]
NCBI Protein Information
telomeric repeat-binding factor 1
UniProt Protein Name
Telomeric repeat-binding factor 1
UniProt Synonym Protein Names
NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
UniProt Gene Name
TERF1  [Similar Products]
UniProt Synonym Gene Names
PIN2; TRBF1; TRF; TRF1  [Similar Products]
UniProt Entry Name
TERF1_HUMAN
NCBI Summary for TERF1
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
UniProt Comments for TERF1
TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: chromosome, telomeric region; cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; spindle

Molecular Function: DNA bending activity; DNA binding; double-stranded telomeric DNA binding; microtubule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; telomerase activity; telomeric DNA binding; ubiquitin binding

Biological Process: cell division; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of DNA replication; negative regulation of telomerase activity; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of telomere maintenance via telomerase; positive regulation of apoptosis; positive regulation of microtubule polymerization; positive regulation of mitosis; positive regulation of mitotic cell cycle; protein homooligomerization; response to drug; telomere clustering; telomere maintenance; telomere maintenance via telomerase
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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