NP_036384.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,558 Da
NCBI Official Full Name
transcription factor EC isoform a
NCBI Official Synonym Full Names
transcription factor EC
NCBI Official Synonym Symbols
TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L [Similar Products]
NCBI Protein Information
transcription factor EC
UniProt Protein Name
Transcription factor EC
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 34; bHLHe34; Transcription factor EC-like; hTFEC-L
UniProt Synonym Gene Names
UniProt Entry Name
TFEC_HUMAN
NCBI Summary for TFEC
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for TFEC
TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: DNA binding; protein binding; protein dimerization activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on TFEC
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Products associated with anti-TFEC antibody
Pathways associated with anti-TFEC antibody
Diseases associated with anti-TFEC antibody
Organs/Tissues associated with anti-TFEC antibody
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