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anti-THBS1 antibody :: Rabbit anti-Human thrombospondin 1 Polyclonal Antibody

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Catalog # MBS712207
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
Product Name

thrombospondin 1 (THBS1), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human thrombospondin 1 polyclonal Antibody

Product Synonym Names
thrombospondin 1; THBS1; THBS; THBS-1; TSP; TSP-1; TSP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
188060
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Immunogen
Human TSP1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12312 / sc-7653 / sc-14013
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-THBS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-THBS1 antibody
ELISA (EIA), Western Blot (WB)

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with THBS1 Antibody at dilution of 1:500 incubated at room temperature for 1.5 hours.
anti-THBS1 antibody SDS-PAGE image
C6 cells were subjected to SDS PAGE followed by western blot with THBS1 Antibody at dilution of 1:500 incubated at room temperature for 1.5 hours
anti-THBS1 antibody SDS-PAGE image
NCBI/Uniprot data below describe general gene information for THBS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,148 Da[Similar Products]
NCBI Official Full Name
thrombospondin-1
NCBI Official Synonym Full Names
thrombospondin 1
NCBI Official Symbol
THBS1  [Similar Products]
NCBI Official Synonym Symbols
TSP; THBS; TSP1; TSP-1; THBS-1
  [Similar Products]
NCBI Protein Information
thrombospondin-1; thrombospondin-1p180
UniProt Protein Name
Thrombospondin-1
Protein Family
UniProt Gene Name
THBS1  [Similar Products]
UniProt Synonym Gene Names
TSP; TSP1  [Similar Products]
UniProt Entry Name
TSP1_HUMAN
NCBI Summary for THBS1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for THBS1
THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: extracellular matrix; extracellular space; cell surface; sarcoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum lumen; fibrinogen complex; extracellular region; secretory granule; external side of plasma membrane

Molecular Function: heparin binding; integrin binding; identical protein binding; proteoglycan binding; protein binding; fibroblast growth factor binding; transforming growth factor beta binding; phosphatidylserine binding; fibronectin binding; laminin binding; low-density lipoprotein binding; calcium ion binding; glycoprotein binding

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; response to magnesium ion; negative regulation of fibrinolysis; response to glucose stimulus; cell cycle arrest; cell adhesion; positive regulation of macrophage activation; response to drug; platelet activation; negative regulation of interleukin-12 production; positive regulation of chemotaxis; positive regulation of blood vessel endothelial cell migration; response to testosterone stimulus; negative regulation of cell-matrix adhesion; negative regulation of blood vessel endothelial cell migration; response to unfolded protein; positive regulation of angiogenesis; response to mechanical stimulus; negative regulation of endothelial cell proliferation; peptide cross-linking; regulation of cGMP metabolic process; response to calcium ion; response to progesterone stimulus; negative regulation of apoptosis; positive regulation of blood coagulation; positive regulation of translation; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of caspase activity; behavioral response to pain; platelet degranulation; protein amino acid O-linked glycosylation; positive regulation of transforming growth factor-beta1 production; positive regulation of tumor necrosis factor biosynthetic process; cell migration; chronic inflammatory response; negative regulation of focal adhesion formation; positive regulation of transforming growth factor beta receptor signaling pathway; engulfment of apoptotic cell; post-translational protein modification; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; cellular protein metabolic process; negative regulation of dendritic cell antigen processing and presentation; response to hypoxia; immune response; sprouting angiogenesis; blood coagulation; positive regulation of phosphorylation; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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