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anti-TRH antibody :: Rabbit anti-Human Thyrotropin Releasing Hormone (TRH) Polyclonal Antibody

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Catalog # MBS2001552 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-TRH antibody
Product Name

Thyrotropin Releasing Hormone (TRH), Polyclonal Antibody

Popular Item
Full Product Name

Biotin-Linked Antibody to Thyrotropin Releasing Hormone (TRH)

Product Gene Name

anti-TRH antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 3; NC_000003.11 (129693236..129696781). Location: 3q13.3-q21
OMIM
613879
3D Structure
ModBase 3D Structure for P20396
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against TRH conjugated to biotin. It has been selected for its ability to recognize TRH in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-TRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Categories/Family for anti-TRH antibody
Biotin Antibody
Applications Tested/Suitable for anti-TRH antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-TRH antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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NCBI/Uniprot data below describe general gene information for TRH. It may not necessarily be applicable to this product.
NCBI GI #
6005920
NCBI GeneID
7200
NCBI Accession #
NP_009048.1 [Other Products]
NCBI GenBank Nucleotide #
NM_007117.4 [Other Products]
UniProt Primary Accession #
P20396 [Other Products]
UniProt Secondary Accession #
Q2TB83; B2R8R1[Other Products]
UniProt Related Accession #
P20396[Other Products]
Molecular Weight
27,404 Da
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NCBI Official Full Name
thyrotropin releasing hormone preproprotein
NCBI Official Synonym Full Names
thyrotropin-releasing hormone
NCBI Official Symbol
TRH  [Similar Products]
NCBI Official Synonym Symbols
TRF; Pro-TRH
  [Similar Products]
NCBI Protein Information
thyrotropin releasing hormone; protirelin; prothyroliberin; TSH-releasing factor; thyrotropin-releasing factor; pro-thyrotropin-releasing hormone
UniProt Protein Name
Pro-thyrotropin-releasing hormone
UniProt Synonym Protein Names
ProthyroliberinCleaved into the following chain:Thyrotropin-releasing hormone; TRH; Alternative name(s):; Protirelin; TSH-releasing factor; Thyroliberin; Thyrotropin-releasing factor
Protein Family
Thyrotropin-releasing hormone
UniProt Gene Name
TRH  [Similar Products]
UniProt Synonym Gene Names
Pro-TRH; TRH; TRF  [Similar Products]
UniProt Entry Name
TRH_HUMAN
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NCBI Summary for TRH
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
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UniProt Comments for TRH
TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. Belongs to the TRH family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: extracellular region; plasma membrane; nucleus; secretory granule

Molecular Function: neuropeptide hormone activity; thyrotropin-releasing hormone activity

Biological Process: hormone-mediated signaling; negative regulation of glutamate secretion; eating behavior; positive regulation of insulin secretion; histamine metabolic process; signal transduction; adult walking behavior; response to ethanol; cell-cell signaling; response to hypoxia; response to glucose stimulus; response to cold; positive regulation of gamma-aminobutyric acid secretion; response to corticosterone stimulus

Disease: Thyrotropin-releasing Hormone Deficiency
Research Articles on TRH
1. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withanti-TRH antibody
 Reference Product  PubMed Publications
 PRL antibody  >1753 publications with TRH and PRL
 GHRH antibody  >252 publications with TRH and GHRH
 CCK antibody  >63 publications with TRH and CCK
 TRHR antibody  >47 publications with TRH and TRHR
 NTS antibody  >16 publications with TRH and NTS
 GRP antibody  >8 publications with TRH and GRP
 GCG antibody  >2 publications with TRH and GCG
 GNRH1 antibody  >1 publications with TRH and GNRH1
Pathways associated with anti-TRH antibody
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram
Diseases associated with anti-TRH antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1994 publications with TRH and Nervous System Diseases
 Brain Diseases Antibodies  >1679 publications with TRH and Brain Diseases
 THYROTROPIN-RELEASING HORMONE DEFICIENCY Antibodies  >285 publications with TRH and THYROTROPIN-RELEASING HORMONE DEFICIENCY
 Disease Models, Animal Antibodies  >131 publications with TRH and Disease Models, Animal
 Bipolar Disorder Antibodies  >102 publications with TRH and Bipolar Disorder
 Seizures Antibodies  >94 publications with TRH and Seizures
 Hypertension Antibodies  >93 publications with TRH and Hypertension
 Hypothermia Antibodies  >91 publications with TRH and Hypothermia
 Pain Antibodies  >84 publications with TRH and Pain
 Movement Disorders Antibodies  >60 publications with TRH and Movement Disorders
Organs/Tissues associated with anti-TRH antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4641 publications with TRH and Brain
 Ovary Antibodies  >124 publications with TRH and Ovary
 Lung Antibodies  >113 publications with TRH and Lung
 Eye Antibodies  >110 publications with TRH and Eye
 Pineal Gland Antibodies  >48 publications with TRH and Pineal Gland
 Bone Marrow Antibodies  >12 publications with TRH and Bone Marrow
 Cervix Antibodies  >3 publications with TRH and Cervix
 Uncharacterized Tissue Antibodies  >1 publications with TRH and Uncharacterized Tissue
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