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anti-TICAM1 antibody :: Rabbit anti-Human TICAM1 / TRIF Polyclonal Antibody

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Catalog # MBS240996
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

TICAM1 / TRIF, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human TICAM1 / TRIF

Product Synonym Names
Anti-TICAM1 / TRIF Antibody (C-Terminus) IHC-plus; TICAM1; IIAE6; TRIF; PRVTIRB; TICAM-1; Human TICAM1; TRIF
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614850
3D Structure
ModBase 3D Structure for Q8IUC6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Peptide comprised of 14 amino acids from the C-terminus of human TICAM1
Purity/Purification
Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human TICAM1 / TRIF.
Immunogen Type
Synthetic peptide
Immunogen
TICAM1 / TRIF antibody was raised against synthetic peptide from human TICAM1 / TRIF.
Antigen Modification
C-Terminus
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TICAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TICAM1 antibody
TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules.
Applications Tested/Suitable for anti-TICAM1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TICAM1 antibody
IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-TICAM1 antibody
Anti-TICAM1 / TRIF antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TICAM1 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-TICAM1 antibody
Western blot of TRIF in human lung cell lysates with TRIF antibody at (A) 2 and (B) 4 g/ml.
anti-TICAM1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TICAM1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,422 Da
NCBI Official Full Name
TIR domain-containing adapter molecule 1
NCBI Official Synonym Full Names
toll-like receptor adaptor molecule 1
NCBI Official Symbol
TICAM1  [Similar Products]
NCBI Official Synonym Symbols
TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
  [Similar Products]
NCBI Protein Information
TIR domain-containing adapter molecule 1; putative NF-kappa-B-activating protein 502H; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
UniProt Protein Name
TIR domain-containing adapter molecule 1
UniProt Synonym Protein Names
Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta
UniProt Gene Name
TICAM1  [Similar Products]
UniProt Synonym Gene Names
PRVTIRB; TRIF; TICAM-1; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta  [Similar Products]
UniProt Entry Name
TCAM1_HUMAN
NCBI Summary for TICAM1
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
UniProt Comments for TICAM1
TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: endosome membrane; cytosol

Molecular Function: protein binding; signal transducer activity; protein kinase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; positive regulation of chemokine biosynthetic process; response to exogenous dsRNA; positive regulation of protein ubiquitination; positive regulation of interferon-beta biosynthetic process; macrophage activation during immune response; positive regulation of B cell proliferation; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; innate immune response; inflammatory response; defense response to virus; toll-like receptor 4 signaling pathway

Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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