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anti-TL1A antibody :: Rabbit anti-Human TL1A TL1A Polyclonal Antibody

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Catalog # MBS535934
Unit / Price
  0.05 mg  /  $370 +1 FREE 8GB USB
anti-TL1A antibody
Product Name

TL1A, Polyclonal Antibody

Also Known As

TL1A antibody

Product Synonym Names
Polyclonal TL1A; Anti-TL1A; TL1A; TLA-1; TL-1A; TLA 1; TNFSF15; VEGI
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
251
OMIM
604052
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human TL1A
Form/Format
Lyophilized from PBS, pH 7.2.
Biological Significance
TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF kb activation, caspase activity, and apoptosis in responding cell lines.
Immunogen
TL1A antibody was raised in rabbit using highly pure recombinant human TL-1A as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-TL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TL1A antibody
Affinity purified Rabbit polyclonal TL1A antibody
Applications Tested/Suitable for anti-TL1A antibody
ELISA (EIA), Inhibition, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TL1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22.0 kDa (predicted detection band MW)
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 15 isoform VEGI-251
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 15
NCBI Official Symbol
TNFSF15  [Similar Products]
NCBI Official Synonym Symbols
TL1; TL1A; VEGI; VEGI192A
  [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 15
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 15
UniProt Synonym Protein Names
TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
UniProt Gene Name
TNFSF15  [Similar Products]
UniProt Synonym Gene Names
TL1; VEGI  [Similar Products]
UniProt Entry Name
TNF15_HUMAN
NCBI Summary for TL1A
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for TL1A
TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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