NP_004286.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,841 Da
NCBI Official Full Name
TNF receptor-associated factor 4
NCBI Official Synonym Full Names
TNF receptor associated factor 4
NCBI Protein Information
TNF receptor-associated factor 4
UniProt Protein Name
TNF receptor-associated factor 4
UniProt Synonym Protein Names
Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
UniProt Synonym Gene Names
NCBI Summary for TRAF4
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TRAF4
TRAF4: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; DNA-binding
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: bicellular tight junction; cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: DNA binding; identical protein binding; protein binding; protein kinase binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; WW domain binding; zinc ion binding
Biological Process: activation of NF-kappaB-inducing kinase; apoptosis; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; positive regulation of protein kinase activity; regulation of apoptosis; respiratory gaseous exchange; respiratory tube development; signal transduction
Research Articles on TRAF4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-TRAF4 antibody
Pathways associated with anti-TRAF4 antibody
Diseases associated with anti-TRAF4 antibody
Organs/Tissues associated with anti-TRAF4 antibody
|