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anti-TR antibody :: Rabbit anti-Human Tomoregulin Polyclonal Antibody

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Catalog # MBS2026100 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $190 +1 FREE 8GB USB
  0.1 mg  /  $245 +1 FREE 8GB USB
  0.2 mg  /  $370 +1 FREE 8GB USB
  1 mg  /  $875 +1 FREE 8GB USB
Product Name

Tomoregulin (TR), Polyclonal Antibody

Popular Item
Also Known As

Polyclonal Antibody to Tomoregulin (TR)

Product Gene Name
Matching Pairs
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
APC-CY7 Conjugated Antibody: Tomoregulin (TR) (MBS2083843)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
PE Conjugated Antibody: Tomoregulin (TR) (MBS2083844)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
APC-CY7 Conjugated Antibody: Tomoregulin (TR) (MBS2083845)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
Cy3 Conjugated Antibody: Tomoregulin (TR) (MBS2083846)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
FITC Conjugated Antibody: Tomoregulin (TR) (MBS2083847)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
HRP Conjugated Antibody: Tomoregulin (TR) (MBS2083848)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
Matching Pairs
Unconjugated Antibody: Tomoregulin (MBS2026100)
Biotin Conjugated Antibody: Tomoregulin (TR) (MBS2096961)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AB017269 mRNA
3D Structure
ModBase 3D Structure for Q9UIK5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a Rabbit polyclonal antibody raised against TR. It has been selected for its ability to recognize TR in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific Affinity Chromatography
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
Concentration
200ug/ml (lot specific)
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant tomoregulin (Thr52~Arg290) expressed in E.coli
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2083845
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of anti-TR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TR antibody
WB; IHC; ICC; IP.
Application Notes for anti-TR antibody
Western blotting: 0.5-2µg/mL
Immunocytochemistry in formalin fixed cells: 5-20µg/mL
Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL
Immunohistochemistry in paraffin section: 5-20µg/mL

Optimal working dilutions must be determined by end user

Western Blot (WB) of anti-TR antibody
Western Blot: Sample: Recombinant Tomoregulin, Human.
anti-TR antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TR antibody
DAB staining on fromalin fixed paraffin- embedded Kidney tissue)
anti-TR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,472 Da
NCBI Official Full Name
tomoregulin-2 isoform 2
NCBI Official Synonym Full Names
transmembrane protein with EGF like and two follistatin like domains 2
NCBI Official Symbol
TMEFF2  [Similar Products]
NCBI Official Synonym Symbols
TR; HPP1; TPEF; TR-2; TENB2; CT120.2
  [Similar Products]
NCBI Protein Information
tomoregulin-2
UniProt Protein Name
Tomoregulin-2
UniProt Synonym Protein Names
Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains
Protein Family
UniProt Gene Name
TMEFF2  [Similar Products]
UniProt Synonym Gene Names
HPP1; TENB2; TPEF; TR-2  [Similar Products]
NCBI Summary for TR
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for TR
TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: extracellular region; integral component of membrane

Biological Process: negative regulation of cell migration; negative regulation of integrin biosynthetic process; negative regulation of stress fiber formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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