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anti-TFRC antibody :: Rabbit anti-Human Transferrin receptor protein 1 Polyclonal Antibody

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Catalog # MBS7000681
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Transferrin receptor protein 1 (TFRC), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Transferrin receptor protein 1 polyclonal Antibody

Product Synonym Names
T9; p90; CD71; TFRC
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Transferrin receptor protein 1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7087 / sc-9099
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TFRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TFRC antibody
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Product Categories/Family for anti-TFRC antibody
Applications Tested/Suitable for anti-TFRC antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TFRC antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-TFRC antibody
Western blot
All lanes: Transferrin receptor protein 1 antibody at 2ug/ml
Lane 1:U251 whole cell lysate
Lane 2:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 85kDa
Observed band size: 85kDa

anti-TFRC antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TFRC antibody
Immunohistochemistry of paraffin-embedded human placenta using MBS7000681 at dilution 1:100
anti-TFRC antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-TFRC antibody
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: TFRC antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 85 KDa
Observed band size: 85 KDa

anti-TFRC antibody Western Blot (WB) (WB) image
Immunocytochemistry (IHC) of anti-TFRC antibody
Immunocytochemistry analysis of human colon cancer using MBS7000681 at dilution of 1:100
anti-TFRC antibody Immunocytochemistry (IHC) (ICC) image
Immunofluorescence (IF) of anti-TFRC antibody
Immunofluorescent analysis of HepG2 cells using MBS7000681 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TFRC antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,871 Da[Similar Products]
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
  [Similar Products]
NCBI Protein Information
transferrin receptor protein 1
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
UniProt Gene Name
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR  [Similar Products]
UniProt Entry Name
TFR1_HUMAN
NCBI Summary for TFRC
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Comments for TFRC
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; melanosome; membrane; mitochondrion; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane

Molecular Function: chaperone binding; double-stranded RNA binding; glycoprotein binding; Hsp70 protein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity; viral receptor activity

Biological Process: acute-phase response; aging; cellular iron ion homeostasis; entry of virus into host cell; osteoclast differentiation; positive regulation of bone resorption; receptor-mediated endocytosis; regulation of cell growth; regulation of cell proliferation; response to copper ion; response to hypoxia; response to iron ion; response to manganese ion; response to nutrient; response to retinoic acid; transferrin transport; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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