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anti-TRIB2 antibody :: Rabbit anti-Human TRIB2 Polyclonal Antibody

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Catalog # MBS628598
Unit / Price
  0.2 mL  /  $550 +1 FREE 8GB USB
anti-TRIB2 antibody
Product Name

TRIB2, Polyclonal Antibody

Also Known As

TRIB2, NT (Tribbles Homolog 2, TRB-2, TRB2)

Product Synonym Names
Anti -TRIB2, NT (Tribbles Homolog 2, TRB-2, TRB2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (12856998..12882860). Location: 2p24.3
OMIM
609462
3D Structure
ModBase 3D Structure for Q92519
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human TRIB2.
Purity/Purification
Affinity Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the N-terminal region of human TRIB2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TRIB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRIB2 antibody
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Applications Tested/Suitable for anti-TRIB2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TRIB2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
NCBI/Uniprot data below describe general gene information for TRIB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,801 Da[Similar Products]
NCBI Official Full Name
tribbles homolog 2
NCBI Official Synonym Full Names
tribbles homolog 2 (Drosophila)
NCBI Official Symbol
TRIB2  [Similar Products]
NCBI Official Synonym Symbols
C5FW; TRB2; GS3955; FLJ57420
  [Similar Products]
NCBI Protein Information
tribbles homolog 2; OTTHUMP00000115687
UniProt Protein Name
Tribbles homolog 2
Protein Family
UniProt Gene Name
TRIB2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TRIB2_HUMAN
NCBI Summary for TRIB2
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
UniProt Comments for TRIB2
TRB2: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; Trbl family

Chromosomal Location of Human Ortholog: 2p24.3

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein kinase inhibitor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; nucleotide binding; transcription factor binding; protein kinase activity

Biological Process: negative regulation of interleukin-10 biosynthetic process; regulation of MAP kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein kinase activity; negative regulation of fat cell differentiation; protein amino acid phosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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