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anti-TRIM23 antibody :: Rabbit anti-Human TRIM23 Polyclonal Antibody

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Catalog # MBS7044622
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

TRIM23, Polyclonal Antibody

Popular Item
Full Product Name

TRIM23 Antibody

Product Synonym Names
E3 ubiquitin-protein ligase TRIM23; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23; TRIM23; ARD1; ARFD1; RNF46
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601747
3D Structure
ModBase 3D Structure for P36406
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human E3 ubiquitin-protein ligase TRIM23 protein (N-280AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26292 / sc-130046
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TRIM23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRIM23 antibody
Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
Applications Tested/Suitable for anti-TRIM23 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-TRIM23 antibody
Western blot
All lanes: TRIM23 antibody at 2.67 ug/ml+ Raw264.7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 65,64,62 kDa
Observed band size: 64 kDa

anti-TRIM23 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TRIM23 antibody
Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7044622 at dilution of 1:100
anti-TRIM23 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TRIM23. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,068 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase TRIM23 isoform alpha
NCBI Official Synonym Full Names
tripartite motif containing 23
NCBI Official Symbol
TRIM23  [Similar Products]
NCBI Official Synonym Symbols
ARD1; ARFD1; RNF46
  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase TRIM23
UniProt Protein Name
E3 ubiquitin-protein ligase TRIM23
UniProt Synonym Protein Names
ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23
UniProt Gene Name
TRIM23  [Similar Products]
UniProt Synonym Gene Names
ARD1; ARFD1; RNF46  [Similar Products]
UniProt Entry Name
TRI23_HUMAN
NCBI Summary for TRIM23
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM23
TRIM23: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: Golgi membrane; lysosomal membrane

Molecular Function: enzyme activator activity; GDP binding; GTP binding; GTPase activity; identical protein binding; protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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