NP_005073.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
70,973 Da
NCBI Official Full Name
E3 ubiquitin/ISG15 ligase TRIM25
NCBI Official Synonym Full Names
tripartite motif containing 25
NCBI Protein Information
E3 ubiquitin/ISG15 ligase TRIM25
UniProt Protein Name
E3 ubiquitin/ISG15 ligase TRIM25
UniProt Synonym Protein Names
Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase (EC:2.3.2.27
UniProt Synonym Gene Names
UniProt Entry Name
TRI25_HUMAN
NCBI Summary for TRIM25
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM25
TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.
Protein type: EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; nucleoplasm
Molecular Function: protein binding; transcription factor activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; innate immune response; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus
Research Articles on TRIM25
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Products associated with anti-TRIM25 antibody
Pathways associated with anti-TRIM25 antibody
Diseases associated with anti-TRIM25 antibody
Organs/Tissues associated with anti-TRIM25 antibody
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