NP_001170781.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 6 isoform b
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 6
NCBI Protein Information
transient receptor potential cation channel subfamily M member 6; channel kinase 2; OTTHUMP00000021487; melastatin-related TRP cation channel 6
UniProt Protein Name
Transient receptor potential cation channel, subfamily M, member 6
UniProt Entry Name
Q5VYG5_HUMAN
NCBI Summary for TRPM6
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
UniProt Comments for TRPM6
ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.
Protein type: Protein kinase, atypical; Channel, cation; Membrane protein, integral; Kinase, protein; Membrane protein, multi-pass; EC 2.7.11.1; ATYPICAL group; Alpha family; ChaK subfamily
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; calcium channel activity; ATP binding
Biological Process: response to toxin; transmembrane transport; protein amino acid phosphorylation
Disease: Hypomagnesemia 1, Intestinal
Research Articles on TRPM6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-TRPM6 antibody
Pathways associated with anti-TRPM6 antibody
Diseases associated with anti-TRPM6 antibody
Organs/Tissues associated with anti-TRPM6 antibody
|