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anti-TSC22D3 antibody :: Rabbit anti-Human TSC22D3 Polyclonal Antibody

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Catalog # MBS7000428
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

TSC22D3, Polyclonal Antibody

Popular Item
Full Product Name

TSC22D3 Antibody

Product Synonym Names
TSC22 domain family protein 3; DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R; TSC22D3; DSIPI; GILZ
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
300506
3D Structure
ModBase 3D Structure for Q99576
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human TSC22 domain family protein 3 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26518 / sc-26519 / sc-26520 / sc-33780
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TSC22D3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSC22D3 antibody
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Applications Tested/Suitable for anti-TSC22D3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-TSC22D3 antibody
Western blot
All lanes: TSC22D3 antibody at 9ug/ml+ Colo320 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 15,23,14 kDa
Observed band size: 15 kDa

anti-TSC22D3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TSC22D3 antibody
Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7000428 at dilution 1:100
anti-TSC22D3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TSC22D3 antibody
Immunohistochemistry of paraffin-embedded human liver cancer using MBS7000428 at dilution 1:100
anti-TSC22D3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TSC22D3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,286 Da
NCBI Official Full Name
TSC22 domain family protein 3 isoform 3
NCBI Official Synonym Full Names
TSC22 domain family member 3
NCBI Official Symbol
TSC22D3  [Similar Products]
NCBI Official Synonym Symbols
DIP; GILZ; DSIPI; TSC-22R
  [Similar Products]
NCBI Protein Information
TSC22 domain family protein 3
UniProt Protein Name
TSC22 domain family protein 3
UniProt Synonym Protein Names
DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R
UniProt Gene Name
TSC22D3  [Similar Products]
UniProt Synonym Gene Names
DSIPI; GILZ; Protein DIP; hDIP; GILZ; TSC-22R  [Similar Products]
UniProt Entry Name
T22D3_HUMAN
NCBI Summary for TSC22D3
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for TSC22D3
GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: cytosol; nucleus

Molecular Function: MRF binding; protein binding; transcription factor activity

Biological Process: negative regulation of skeletal muscle development; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to osmotic stress; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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