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anti-HCK antibody :: Rabbit anti-Human Tyrosine-protein kinase HCK Polyclonal Antibody

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Catalog # MBS1498941
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Tyrosine-protein kinase HCK, Polyclonal Antibody

Full Product Name

Rabbit anti-human Tyrosine-protein kinase HCK polyclonal Antibody(HCK)

Product Synonym Names
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck; HCK
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
142370
3D Structure
ModBase 3D Structure for P08631
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Tyrosine-protein kinase HCK protein(1-220aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-72 / sc-11401
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HCK antibody
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Applications Tested/Suitable for anti-HCK antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-HCK antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-HCK antibody
Immunohistochemistry of paraffin-embedded human tonsil using MBS1498941 at dilution 1:100
anti-HCK antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HCK antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS1498941 at dilution 1:100
anti-HCK antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,529 Da
NCBI Official Full Name
tyrosine-protein kinase HCK isoform b
NCBI Official Synonym Full Names
HCK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
JTK9; p59Hck; p61Hck
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NCBI Protein Information
tyrosine-protein kinase HCK
UniProt Protein Name
Tyrosine-protein kinase HCK
UniProt Synonym Protein Names
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck
Protein Family
UniProt Gene Name
UniProt Entry Name
HCK_HUMAN
NCBI Summary for HCK
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
UniProt Comments for HCK
Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: actin filament; caveola; cell projection; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; nucleus; transport vesicle

Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell adhesion; cell differentiation; cytokine and chemokine mediated signaling pathway; inflammatory response; innate immune response; innate immune response-activating signal transduction; integrin-mediated signaling pathway; leukocyte degranulation; leukocyte migration during immune response; lipopolysaccharide-mediated signaling pathway; mesoderm development; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape; regulation of defense response to virus by virus; regulation of inflammatory response; regulation of phagocytosis; regulation of transcription factor activity; respiratory burst after phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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