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anti-YARS antibody :: Rabbit anti-Human Tyrosyl-tRNA synthetase, cytoplasmic Polyclonal Antibody

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Catalog # MBS7000025
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Tyrosyl-tRNA synthetase, cytoplasmic (YARS), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Tyrosyl-tRNA synthetase, cytoplasmic polyclonal Antibody

Product Synonym Names
YARS; Tyrosyl--tRNA ligase; TyrRS
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603623
3D Structure
ModBase 3D Structure for P54577
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Tyrosyl-tRNA synthetase, cytoplasmic protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26209 / sc-26207
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-YARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-YARS antibody
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
Product Categories/Family for anti-YARS antibody
Applications Tested/Suitable for anti-YARS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-YARS antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-YARS antibody
Western blot
All lanes: Tyrosyl-tRNA synthetase, cytoplasmic Antibody at 2ug/ml+293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

anti-YARS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-YARS antibody
Immunohistochemistry of paraffin-embeded human kidney using MBS7000025 at dilution of 1:50
anti-YARS antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for YARS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,143 Da[Similar Products]
NCBI Official Full Name
tyrosine--tRNA ligase, cytoplasmic
NCBI Official Synonym Full Names
tyrosyl-tRNA synthetase
NCBI Official Symbol
NCBI Official Synonym Symbols
YRS; YTS; TYRRS; CMTDIC
  [Similar Products]
NCBI Protein Information
tyrosine--tRNA ligase, cytoplasmic
UniProt Protein Name
Tyrosine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Tyrosyl-tRNA synthetase; TyrRS
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
TyrRS  [Similar Products]
UniProt Entry Name
SYYC_HUMAN
NCBI Summary for YARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
UniProt Comments for YARS
YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family.

Protein type: EC 6.1.1.1; Ligase

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: cytoplasm; cytosol; extracellular space; nucleus

Molecular Function: ATP binding; interleukin-8 receptor binding; signal transducer activity; tRNA binding; tyrosine-tRNA ligase activity; valine-tRNA ligase activity

Biological Process: apoptosis; gene expression; signal transduction; tRNA aminoacylation for protein translation; tyrosyl-tRNA aminoacylation

Disease: Charcot-marie-tooth Disease, Dominant Intermediate C
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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