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anti-Ube2d2a antibody :: Rabbit anti-Human UBE2D2 Polyclonal Antibody

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Catalog # MBS6012359
Unit / Price
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  0.2 mL  /  $610 +1 FREE 8GB USB
anti-Ube2d2a antibody
Product Name

UBE2D2 (Ube2d2a), Polyclonal Antibody

Popular Item
Full Product Name

UBE2D2, CT (UBE2D2, UBC4, UBC5B, UBCH4, UBCH5B, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating enzyme E2-17kD 2, Ubiquitin-protein ligase D2)

Product Synonym Names
Anti -UBE2D2, CT (UBE2D2, UBC4, UBC5B, UBCH4, UBCH5B, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating enzyme E2-17kD 2, Ubiquitin-protein ligase D2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 18; NC_000084.6 (35771559..35807172). Location: 18 B2; 18
3D Structure
ModBase 3D Structure for P62838
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Human
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
UBE2D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the C-terminal region of human UBE2D2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-Ube2d2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Ube2d2a antibody
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Applications Tested/Suitable for anti-Ube2d2a antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Ube2d2a antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for Ube2d2a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,735 Da[Similar Products]
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 D2
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2D 2A
NCBI Official Symbol
Ube2d2a  [Similar Products]
NCBI Official Synonym Symbols
ubc4; Ubc2e; Ube2d2; 1500034D03Rik
  [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 D2; E2(17)KB 2; ubiquitin-protein ligase D2; ubiquitin carrier protein D2; ubiquitin conjugating enzyme 2e; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kDa 2
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 D2
UniProt Synonym Protein Names
Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2
UniProt Gene Name
Ube2d2  [Similar Products]
UniProt Synonym Gene Names
Ubc4; Ubch4; Ubch5b; Ube2d2a  [Similar Products]
UniProt Entry Name
UB2D2_MOUSE
UniProt Comments for Ube2d2a
UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: protein complex; ubiquitin ligase complex

Molecular Function: protein binding; nucleotide binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: protein polyubiquitination; protein ubiquitination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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