EAW93233.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,696 Da
NCBI Official Full Name
ubiquilin 2
NCBI Official Synonym Full Names
ubiquilin 2
NCBI Official Synonym Symbols
DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157 [Similar Products]
NCBI Protein Information
ubiquilin-2
UniProt Protein Name
Ubiquilin-2
UniProt Synonym Protein Names
Chap1; DSK2 homolog; Protein linking IAP with cytoskeleton 2; PLIC-2; hPLIC-2; Ubiquitin-like product Chap1/Dsk2
UniProt Synonym Gene Names
NCBI Summary for UBQLN2
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
UniProt Comments for UBQLN2
UBQLN2: Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation. Defects in UBQLN2 are the cause of amyotrophic lateral sclerosis type 15 with or without frontotemporal dementia (ALS15). A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: ER-associated protein catabolic process; regulation of macroautophagy
Disease: Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia
Research Articles on UBQLN2
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Products associated with anti-UBQLN2 antibody
Pathways associated with anti-UBQLN2 antibody
Diseases associated with anti-UBQLN2 antibody
Organs/Tissues associated with anti-UBQLN2 antibody
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