EAW48020.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
vanin 1
NCBI Official Synonym Full Names
vanin 1
NCBI Protein Information
pantetheinase; vanin-1; vannin 1; pantetheine hydrolase; vascular non-inflammatory molecule 1
UniProt Protein Name
Pantetheinase
UniProt Synonym Protein Names
Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1
UniProt Synonym Gene Names
UniProt Entry Name
VNN1_HUMAN
NCBI Summary for VNN1
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
UniProt Comments for VNN1
VNN1: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Hydrolase; Membrane protein, GPI anchor; EC 3.5.1.92; Membrane protein, integral; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis
Chromosomal Location of Human Ortholog: 6q23-q24
Cellular Component: integral to membrane; plasma membrane
Molecular Function: pantetheine hydrolase activity
Biological Process: positive regulation of T cell differentiation in the thymus; cell-cell adhesion; chronic inflammatory response; pantothenate metabolic process; innate immune response; response to oxidative stress; inflammatory response; cell motility; acute inflammatory response
Research Articles on VNN1
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Products associated with anti-VNN1 antibody
Pathways associated with anti-VNN1 antibody
Diseases associated with anti-VNN1 antibody
Organs/Tissues associated with anti-VNN1 antibody
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