NP_000304.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
vitamin K-dependent protein S isoform 2 preproprotein
NCBI Official Synonym Full Names
protein S (alpha)
NCBI Official Synonym Symbols
PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6 [Similar Products]
NCBI Protein Information
vitamin K-dependent protein S
UniProt Protein Name
Vitamin K-dependent protein S
UniProt Synonym Gene Names
UniProt Entry Name
PROS_HUMAN
NCBI Summary for PROS1
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
UniProt Comments for PROS1
PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3q11.2
Cellular Component: endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi lumen; Golgi membrane; plasma membrane; protein complex
Molecular Function: calcium ion binding; endopeptidase inhibitor activity; protein complex binding
Biological Process: blood coagulation; cellular protein metabolic process; ER to Golgi vesicle-mediated transport; fibrinolysis; innate immune response; leukocyte migration; peptidyl-glutamic acid carboxylation; platelet activation; platelet degranulation; positive regulation of phagocytosis; post-translational protein modification; regulation of complement activation; response to lipopolysaccharide; signal peptide processing
Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Dominant; Thrombophilia Due To Protein S Deficiency, Autosomal Recessive
Research Articles on PROS1
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Products associated with anti-PROS1 antibody
Pathways associated with anti-PROS1 antibody
Diseases associated with anti-PROS1 antibody
Organs/Tissues associated with anti-PROS1 antibody
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