NP_001316323.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,148 Da
NCBI Official Full Name
vacuole membrane protein 1 isoform 1
NCBI Official Synonym Full Names
vacuole membrane protein 1
NCBI Protein Information
vacuole membrane protein 1
UniProt Protein Name
Vacuole membrane protein 1
UniProt Synonym Protein Names
Transmembrane protein 49
UniProt Synonym Gene Names
NCBI Summary for VMP1
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
UniProt Comments for VMP1
VMP1: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2. Belongs to the VMP1 family.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: endoplasmic reticulum; membrane; nucleolus
Molecular Function: protein binding
Biological Process: cell-cell adhesion; endoplasmic reticulum organization and biogenesis; exocytosis; Golgi organization and biogenesis; regulation of autophagy
Research Articles on VMP1
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Products associated with anti-VMP1 antibody
Pathways associated with anti-VMP1 antibody
Diseases associated with anti-VMP1 antibody
Organs/Tissues associated with anti-VMP1 antibody
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