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anti-VSIG4 antibody :: Rabbit anti-Human VSIG4 Polyclonal Antibody

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Catalog # MBS9215155
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

VSIG4, Polyclonal Antibody

Popular Item
Full Product Name

VSIG4 Antibody (C-term)

Product Synonym Names
V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; VSIG4; CRIg; Z39IG
Antibody/Peptide Pairs
VSIG4 peptide (MBS9223836) is used for blocking the activity of VSIG4 antibody (MBS9215155)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
308-335
OMIM
300353
3D Structure
ModBase 3D Structure for Q9Y279
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB39950
Host
Rabbit
Species Reactivity
Human
Specificity
This VSIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the C-terminal region of human VSIG4.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Cellular Location
Membrane; Single-pass type I membrane protein
Tissue Location
Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta Expressed in resting macrophages.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-VSIG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-VSIG4 antibody
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
Product Categories/Family for anti-VSIG4 antibody
Applications Tested/Suitable for anti-VSIG4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-VSIG4 antibody
WB~~1:1000

Western Blot (WB) of anti-VSIG4 antibody
VSIG4 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the VSIG4 antibody detected the VSIG4 protein (arrow).
anti-VSIG4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for VSIG4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43987
NCBI Official Full Name
V-set and immunoglobulin domain-containing protein 4 isoform 2
NCBI Official Synonym Full Names
V-set and immunoglobulin domain containing 4
NCBI Official Symbol
VSIG4  [Similar Products]
NCBI Official Synonym Symbols
CRIg; Z39IG
  [Similar Products]
NCBI Protein Information
V-set and immunoglobulin domain-containing protein 4
UniProt Protein Name
V-set and immunoglobulin domain-containing protein 4
UniProt Synonym Protein Names
Protein Z39Ig
UniProt Gene Name
VSIG4  [Similar Products]
UniProt Synonym Gene Names
CRIg; Z39IG  [Similar Products]
UniProt Entry Name
VSIG4_HUMAN
NCBI Summary for VSIG4
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for VSIG4
VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq12-q13.3

Cellular Component: integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; complement activation, alternative pathway; negative regulation of interleukin-2 production
Product References and Citations for anti-VSIG4 antibody
Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)
Van Loo, P., et al. Haematologica 95(3):440-448(2010)
Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)
He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)
Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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