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anti-WNT4 antibody :: Rabbit anti-Human WNT4 Polyclonal Antibody

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Catalog # MBS7004162
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

WNT4, Polyclonal Antibody

Popular Item
Also Known As

WNT4 Antibody

Product Synonym Names
Protein Wnt-4; WNT4; UNQ426/PRO864
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
351
OMIM
158330
3D Structure
ModBase 3D Structure for P56705
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human Protein Wnt-4 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5215 / sc-5214 / sc-13962
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-WNT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-WNT4 antibody
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
Applications Tested/Suitable for anti-WNT4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-WNT4 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-WNT4 antibody
Western blot
All lanes: WNT4 antibody at 8ug/ml+ MCF7 whole cell lysate
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 40,33 kDa
Observed band size: 39 kDa

anti-WNT4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-WNT4 antibody
Immunohistochemistry of paraffin-embedded human testis using MBS7004162 at dilution of 1:100
anti-WNT4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-WNT4 antibody
Immunohistochemistry of paraffin-embedded human heart using MBS7004162 at dilution of 1:100
anti-WNT4 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for WNT4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,954 Da
NCBI Official Full Name
protein Wnt-4
NCBI Official Synonym Full Names
wingless-type MMTV integration site family member 4
NCBI Official Symbol
NCBI Official Synonym Symbols
WNT-4; SERKAL
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NCBI Protein Information
protein Wnt-4
UniProt Protein Name
Protein Wnt-4
UniProt Gene Name
UniProt Entry Name
WNT4_HUMAN
NCBI Summary for WNT4
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for WNT4
WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.23-p35.1

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; proteinaceous extracellular matrix

Molecular Function: frizzled binding; receptor agonist activity; transcription corepressor activity

Biological Process: adrenal gland development; androgen biosynthetic process; cell fate commitment; cellular response to starvation; embryonic epithelial tube formation; epithelial to mesenchymal transition; female gonad development; female sex determination; immature T cell proliferation in the thymus; kidney development; liver development; male gonad development; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; neuron differentiation; oocyte development; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of focal adhesion formation; positive regulation of GTPase activity; positive regulation of meiosis; positive regulation of osteoblast differentiation; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; regulation of cell-cell adhesion; smooth muscle cell differentiation; somatotropin secreting cell differentiation; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs; Mullerian Aplasia And Hyperandrogenism
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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