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anti-XRCC4 antibody :: Rabbit anti-Human XRCC4 Polyclonal Antibody

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Catalog # MBS2537894
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

XRCC4, Polyclonal Antibody

Popular Item
Full Product Name

XRCC4 Polyclonal Antibody

Product Synonym Names
XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
194363
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the C-terminal region of human XRCC4.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-136124 / sc-365055 / sc-365118
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-XRCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-XRCC4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-XRCC4 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-XRCC4 antibody
Western Blot analysis of various cells with XRCC4 Polyclonal Antibody.
anti-XRCC4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for XRCC4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 38
Observed MW: 40
NCBI Official Full Name
XRCC4
NCBI Official Synonym Full Names
X-ray repair complementing defective repair in Chinese hamster cells 4
NCBI Official Symbol
XRCC4  [Similar Products]
NCBI Official Synonym Symbols
SSMED
  [Similar Products]
NCBI Protein Information
DNA repair protein XRCC4
UniProt Protein Name
DNA repair protein XRCC4
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 4
Protein Family
UniProt Gene Name
XRCC4  [Similar Products]
UniProt Entry Name
XRCC4_HUMAN
NCBI Summary for XRCC4
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for XRCC4
XRCC4: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Widely expressed. Belongs to the XRCC4 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: cell junction; centrosome; condensed chromosome; cytosol; DNA ligase IV complex; DNA-dependent protein kinase complex; nucleoplasm; nucleus

Molecular Function: DNA binding; ligase activity; protein binding; protein C-terminus binding

Biological Process: cellular protein metabolic process; DNA ligation during DNA repair; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; positive regulation of ligase activity; post-translational protein modification; protein sumoylation; response to X-ray; viral reproduction

Disease: Short Stature, Microcephaly, And Endocrine Dysfunction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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