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anti-XRCC4 antibody :: Rabbit anti-Human XRCC4 Polyclonal Antibody

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Catalog # MBS2537894
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

XRCC4, Polyclonal Antibody

Popular Item
Full Product Name

XRCC4 Polyclonal Antibody

Product Synonym Names
XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Antigen Affinity Purified
1 mg/ml (lot specific)
Synthesized peptide derived from the C-terminal region of human XRCC4.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-136124 / sc-365055 / sc-365118
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-XRCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-XRCC4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-XRCC4 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-XRCC4 antibody
Western Blot analysis of various cells with XRCC4 Polyclonal Antibody.
anti-XRCC4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for XRCC4. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 38
Observed MW: 40
NCBI Official Full Name
NCBI Official Synonym Full Names
X-ray repair complementing defective repair in Chinese hamster cells 4
NCBI Official Symbol
XRCC4  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
DNA repair protein XRCC4
UniProt Protein Name
DNA repair protein XRCC4
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 4
Protein Family
UniProt Gene Name
XRCC4  [Similar Products]
UniProt Entry Name
NCBI Summary for XRCC4
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for XRCC4
XRCC4: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Widely expressed. Belongs to the XRCC4 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: cell junction; centrosome; condensed chromosome; cytosol; DNA ligase IV complex; DNA-dependent protein kinase complex; nucleoplasm; nucleus

Molecular Function: DNA binding; ligase activity; protein binding; protein C-terminus binding

Biological Process: cellular protein metabolic process; DNA ligation during DNA repair; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; positive regulation of ligase activity; post-translational protein modification; protein sumoylation; response to X-ray; viral reproduction

Disease: Short Stature, Microcephaly, And Endocrine Dysfunction
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