NP_001304941.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 40 kDa Predicted: 39 kDa
NCBI Official Full Name
DNA repair protein XRCC4 isoform 2
NCBI Official Synonym Full Names
X-ray repair cross complementing 4
NCBI Official Synonym Symbols
NCBI Protein Information
DNA repair protein XRCC4
UniProt Protein Name
DNA repair protein XRCC4
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 4
NCBI Summary for XRCC4
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for XRCC4
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Research Articles on XRCC4
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Products associated with anti-XRCC4 antibody
Pathways associated with anti-XRCC4 antibody
Diseases associated with anti-XRCC4 antibody
Organs/Tissues associated with anti-XRCC4 antibody
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