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anti-Slc39a8 antibody :: Rabbit anti-Human ZIP8 Polyclonal Antibody

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Catalog # MBS151012
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ZIP8 (Slc39a8), Polyclonal Antibody

Full Product Name

ZIP8 Antibody

Product Synonym Names
ZIP8; ZIP8; PP3105; BIGM103; LZT-Hs6; ZIP8; Zinc transporter ZIP8; BCG-induced integral membrane protein in monocyte clone 103 protein; solute carrier family 39 (zinc transporter), member 8
Antibody/Peptide Pairs
ZIP8 peptide (MBS151851) is used for blocking the activity of ZIP8 antibody (MBS151012)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608732
3D Structure
ModBase 3D Structure for Q9C0K1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
ZIP8 antibody is predicted to not cross-react with other ZIP family members.
Purity/Purification
ZIP8 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ZIP8 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZIP8.
Buffer
ZIP8 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ZIP8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-Slc39a8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Slc39a8 antibody
ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
Applications Tested/Suitable for anti-Slc39a8 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-Slc39a8 antibody
ZIP8 antibody can be used for detection of ZIP8 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-Slc39a8 antibody
Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/mL.
anti-Slc39a8 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-Slc39a8 antibody
Immunofluorescence of ZIP8 in human spleen tissue with ZIP8 antibody at 20 μg/mL.
anti-Slc39a8 antibody Immunofluorescence (IF) image
Immunohistochemistry (IHC) of anti-Slc39a8 antibody
Immunohistochemistry of ZIP8 in human spleen tissue with ZIP8 antibody at 5 μg/mL.
anti-Slc39a8 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Slc39a8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,089 Da
NCBI Official Full Name
zinc transporter ZIP8 isoform a
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 8
NCBI Official Symbol
SLC39A8  [Similar Products]
NCBI Official Synonym Symbols
ZIP8; PP3105; BIGM103; LZT-Hs6
  [Similar Products]
NCBI Protein Information
zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8; solute carrier family 39 member 8; LIV-1 subfamily of ZIP zinc transporter 6; BCG induced integral membrane protein BIGM103; solute carrier family 39 (metal ion transporter), member 8; BCG-induced integral membrane protein in monocyte clone 103 protein
UniProt Protein Name
Zinc transporter ZIP8
UniProt Synonym Protein Names
BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8; ZIP-8
Protein Family
UniProt Gene Name
SLC39A8  [Similar Products]
UniProt Synonym Gene Names
BIGM103; ZIP8; LZT-Hs6; ZIP-8  [Similar Products]
UniProt Entry Name
S39A8_HUMAN
NCBI Summary for Slc39a8
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
UniProt Comments for Slc39a8
SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: plasma membrane; integral to membrane

Molecular Function: metal ion transmembrane transporter activity

Biological Process: zinc ion transport; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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