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anti-STAMBP antibody :: Rabbit STAMBP Polyclonal Antibody

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Catalog # MBS621480
Unit / Price
  0.02 mL  /  $385 +1 FREE 8GB USB
  0.1 mL  /  $540 +1 FREE 8GB USB
anti-STAMBP antibody
Product Name

STAMBP, Polyclonal Antibody

Also Known As

STAMBP (STAM binding protein, AMSH, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, MGC126516, MGC126518)

Product Synonym Names
Anti -STAMBP (STAM binding protein, AMSH, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, MGC126516, MGC126518)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (74056086..74090011). Location: 2p13.1
OMIM
606247
3D Structure
ModBase 3D Structure for O95630
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey
Specificity
Recognizes endogenous levels of total STAMBP protein. Species crossreactivity: Human and monkey
Purity/Purification
Affinity Purified
Purified by Protein A and petide affinity chromatography.
Form/Format
Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.
Immunogen
Synthetic peptide corresponding to residues surrounding Gly194 of human STAMBP protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-STAMBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-STAMBP antibody
Protein ubiquitination and deubiquitination is a reversible process catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (1,2). Deubiquitinating enzymes (DUBs) function as ubiquitin-specific proteases and can be divided into five subfamilies based on catalytic domain structure. At least 14 members of the JAMM ubiquitin protease subfamily have been identified, including signal transducing adaptor molecule (STAM) binding protein (3). STAM-binding protein (STAMBP or AMSH) is an endosomal DUB that preferentially displays ubiquitin isopeptidase activity toward K63-linked chains, which is critically dependent upon its interaction with STAM (4,5). STAMBP interacts with the STAM adaptor protein and becomes integrated into the multivesicular body sorting machinery to help regulate endosomal trafficking and receptor tyrosine kinase stability by deubiquitining target proteins (4,6). Evidence indicates that endosomal STAMBP antagonizes the ubiquitin-dependent trafficking of EGFR to the lysosomal compartment (7).
Product Categories/Family for anti-STAMBP antibody
Applications Tested/Suitable for anti-STAMBP antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-STAMBP antibody
Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:50
NCBI/Uniprot data below describe general gene information for STAMBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,077 Da[Similar Products]
NCBI Official Full Name
STAM-binding protein
NCBI Official Synonym Full Names
STAM binding protein
NCBI Official Symbol
STAMBP  [Similar Products]
NCBI Official Synonym Symbols
AMSH; MGC126516; MGC126518
  [Similar Products]
NCBI Protein Information
STAM-binding protein; OTTHUMP00000160249; OTTHUMP00000202512; OTTHUMP00000202513; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM
UniProt Protein Name
STAM-binding protein
UniProt Synonym Protein Names
Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Protein Family
UniProt Gene Name
STAMBP  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
STABP_HUMAN
NCBI Summary for STAMBP
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]
UniProt Comments for STAMBP
AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.

Protein type: Protease; Ubiquitin-specific protease; EC 3.4.19.-; EC 3.1.2.15

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: nucleoplasm; early endosome; cytoplasm; plasma membrane; nucleus; cleavage furrow

Molecular Function: protein domain specific binding; protein binding; metallopeptidase activity; metal ion binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; cytokinesis after mitosis; positive regulation of cell proliferation; negative regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; proteolysis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade

Disease: Microcephaly-capillary Malformation Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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