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anti-RBBP8 antibody :: Rabbit CTIP (pS327) Polyclonal Antibody

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Catalog # MBS821182
Unit / Price
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  0.03 mL  /  $165 +1 FREE 8GB USB
  0.1 mL  /  $245 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
anti-RBBP8 antibody
Product Name

CTIP (pS327) (RBBP8), Polyclonal Antibody

Popular Item
Full Product Name

Anti-CTIP (pS327) Antibody

Product Synonym Names
CTIP; DNA endonuclease RBBP8; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 606744
3D Structure
ModBase 3D Structure for Q99708
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Monkey
Specificity
Recognizes endogenous levels of CTIP (pS327) protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CTIP (pS327). The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-RBBP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RBBP8 antibody
Rabbit polyclonal antibody to CTIP (pS327)
Applications Tested/Suitable for anti-RBBP8 antibody
Western Blot (WB)
Application Notes for anti-RBBP8 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-RBBP8 antibody
anti-RBBP8 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RBBP8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,434 Da
NCBI Official Full Name
DNA endonuclease RBBP8 isoform a
NCBI Official Synonym Full Names
retinoblastoma binding protein 8
NCBI Official Symbol
RBBP8  [Similar Products]
NCBI Official Synonym Symbols
RIM; COM1; CTIP; JWDS; SAE2; SCKL2
  [Similar Products]
NCBI Protein Information
DNA endonuclease RBBP8; RBBP-8; CTBP-interacting protein; sporulation in the absence of SPO11 protein 2 homolog
UniProt Protein Name
DNA endonuclease RBBP8
UniProt Synonym Protein Names
CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2
Protein Family
UniProt Gene Name
RBBP8  [Similar Products]
UniProt Synonym Gene Names
CTIP; CtIP; RBBP-8; RIM; SAE2  [Similar Products]
UniProt Entry Name
COM1_HUMAN
NCBI Summary for RBBP8
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for RBBP8
CtIP: a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner.

Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleoplasm; transcriptional repressor complex; nucleolus; nucleus

Molecular Function: protein binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; meiotic cell cycle; cell division; blastocyst hatching; negative regulation of transcription from RNA polymerase II promoter; G2/M transition DNA damage checkpoint; DNA repair; cell cycle checkpoint; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle

Disease: Jawad Syndrome; Seckel Syndrome 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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