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anti-MYOC antibody :: Rabbit Myocilin Polyclonal Antibody

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Catalog # MBS540475
Unit / Price
  0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Myocilin, Polyclonal Antibody

Popular Item
Also Known As

Rabbit Polyclonal Anti-Myocilin Antibody

Product Synonym Names
Glaucoma 1 open angle; GLC1A; GPOA; JOAG; Mutated trabecular meshwork-induced glucocorticoid response protein; MYOC; Myocilin; TIGR antibody
Matching Pairs
Antibody: Myocilin (MBS540475)
Positive Control: Myocilin (MBS542974)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
490
OMIM
137750
3D Structure
ModBase 3D Structure for Q99972
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Affinity purified immunoglobulins
Concentration
0.72 ug/ul IgG in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide corresponding to N terminal amino acids 25-46 of Myocilin. Peptide was covalently modified and conjugated to KLH.
Preparation and Storage
Store at -20 degree C for long term storage
Other Notes
Small volumes of anti-MYOC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MYOC antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunomicroscopy (IM), Western Blot (WB)
Application Notes for anti-MYOC antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Immunoprecipitation: 1:200
Western Blot: 1:500

Western Blot (WB) of anti-MYOC antibody
WB of Myocilin Antibody with Myocilin Positive Control (#MBS542974). 1:500 antibody dilution in DiluOBuffer (#MBS5400296). Apparent molecular weight is 55kDa.
anti-MYOC antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for MYOC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
Predicted: 55 kDa.[Similar Products]
NCBI Official Full Name
myocilin
UniProt Protein Name
Myocilin
UniProt Synonym Protein Names
Myocilin, N-terminal fragmentAlternative name(s):Myocilin 20 kDa N-terminal fragment
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
MYOC_HUMAN
UniProt Comments for MYOC
MYOC: May participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in MYOC are a cause of primary congenital glaucoma type 3A (GLC3A). An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. MYOC variations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease.

Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23-q24

Cellular Component: cilium; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; endoplasmic reticulum; extracellular matrix; extracellular space; Golgi apparatus; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; proteinaceous extracellular matrix; rough endoplasmic reticulum

Molecular Function: fibronectin binding; frizzled binding; metal ion binding; myosin light chain binding; protein binding; receptor tyrosine kinase binding

Biological Process: clustering of voltage-gated sodium channels; myelination in the peripheral nervous system; negative regulation of cell-matrix adhesion; negative regulation of Rho protein signal transduction; negative regulation of stress fiber formation; neurite development; osteoblast differentiation; positive regulation of cell migration; positive regulation of focal adhesion formation; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; regulation of MAPKKK cascade; skeletal muscle hypertrophy

Disease: Glaucoma 1, Open Angle, A
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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