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anti-PDE10A antibody :: Rabbit Phospho-PDE10A Polyclonal Antibody

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Catalog # MBS540100
Unit / Price
  0.1 mg Affinity-Purified  /  $495 +1 FREE 8GB USB
anti-PDE10A antibody
Product Name

Phospho-PDE10A, Polyclonal Antibody

Also Known As

Phospho-PDE10A Antibody

Product Synonym Names
5''-cyclic phosphodiesterase 10A; cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A; FLJ11894; HSPDE10A; PDE 10A; Pde10a; Phosphodiesterase 10A antibody
Matching Pairs
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
807
OMIM
610652
3D Structure
ModBase 3D Structure for Q9Y233
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.7 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Phosphorylated synthetic MAP common to all PDE10A variants. Taken within amino acid region 1-50 on human PDE10A protein.
Expression
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Modification
Phosphorylated
Molecular Function
Hydrolase, metal-ion binding, cGMP binding
Structure
Homodimer
Subcellular Location
Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-PDE10A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PDE10A antibody
Affinity Purified Phosphorylated Phosphodiesterase 10A Antibody
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Applications Tested/Suitable for anti-PDE10A antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE10A antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for PDE10A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,390 Da
NCBI Official Full Name
3',5'-cyclic nucleotide phosphodiesterase 10A2, partial
NCBI Official Synonym Full Names
phosphodiesterase 10A
NCBI Official Symbol
PDE10A  [Similar Products]
NCBI Official Synonym Symbols
ADSD2; IOLOD; HSPDE10A; PDE10A19
  [Similar Products]
NCBI Protein Information
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
UniProt Protein Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
UniProt Gene Name
PDE10A  [Similar Products]
UniProt Entry Name
PDE10_HUMAN
NCBI Summary for PDE10A
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for PDE10A
PDE10A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytosol; membrane; perikaryon

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding

Biological Process: cAMP catabolic process; cGMP catabolic process; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-PDE10A antibody
 Reference Product  PubMed Publications
 ADCY5 antibody  >1 publications with PDE10A and ADCY5
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