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anti-IQGAP2 antibody :: Rabbit Rac1/Cdc42 Polyclonal Antibody

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Catalog # MBS622474
Unit / Price
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  0.02 mL  /  $385 +1 FREE 8GB USB
  0.1 mL  /  $615 +1 FREE 8GB USB
anti-IQGAP2 antibody
Product Name

Rac1/Cdc42 (IQGAP2), Polyclonal Antibody

Full Product Name

Rac1/Cdc42

Product Synonym Names
Anti -Rac1/Cdc42
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (75699131..76003957). Location: 5q13.3
OMIM
605401
3D Structure
ModBase 3D Structure for Q13576
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Specificity
Recognizes endogenous levels of total rac1 and cdc42 protein. Based on sequence similarities, the antibody may react with rac2 and rac3. The antibody does not cross-react with rhoA, rhoB or rhoC. Species crossreactivity: Human, muse, rat and monkey
Purity/Purification
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Form/Format
Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.
Immunogen
Synthetic peptide corresponding to residues near the amino termini of human rac1 and cdc42.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-IQGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IQGAP2 antibody
Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3).
Applications Tested/Suitable for anti-IQGAP2 antibody
Western Blot (WB)
Application Notes for anti-IQGAP2 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
NCBI/Uniprot data below describe general gene information for IQGAP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
180,578 Da[Similar Products]
NCBI Official Full Name
ras GTPase-activating-like protein IQGAP2
NCBI Official Synonym Full Names
IQ motif containing GTPase activating protein 2
NCBI Official Symbol
IQGAP2  [Similar Products]
NCBI Protein Information
ras GTPase-activating-like protein IQGAP2
UniProt Protein Name
Ras GTPase-activating-like protein IQGAP2
UniProt Gene Name
IQGAP2  [Similar Products]
UniProt Entry Name
IQGA2_HUMAN
NCBI Summary for IQGAP2
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
UniProt Comments for IQGAP2
IQGAP2: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; G protein regulator, misc.

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: filamentous actin; microtubule; microvillus; cell surface; lamellipodium; cytoplasm; actin cytoskeleton; filopodium

Molecular Function: calmodulin binding; actin filament binding; Rho GTPase binding; phosphatidylinositol-3,4,5-triphosphate binding; Rac GTPase binding; actin binding; GTPase inhibitor activity

Biological Process: small GTPase mediated signal transduction; negative regulation of catalytic activity; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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