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anti-CCR5 antibody :: Rabbit CCR5 Polyclonal Antibody

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Catalog # MBS540460
Unit / Price
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  0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
Product Name

CCR5, Polyclonal Antibody

Full Product Name

CCR5 Antibody

Product Synonym Names
AM4 7; CCCKR 5; CD 195; CHEMR13; HIV 1 Fusion Coreceptor; IDDM22; MIP-1 alpha receptor antibody
Matching Pairs
Antibody: CCR5 (MBS540460)
Positive Control: CCR5 (MBS542609)
Antibody/Peptide Pairs
CCR5 peptide (MBS542653) is used for blocking the activity of CCR5 antibody (MBS540460)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601373
3D Structure
ModBase 3D Structure for P51681
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey, Rat
Form/Format
Affinity Purified
Concentration
0.64-0.70 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.
Expression
Spleen, Thymus, myeloid cell line THP-1, promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Lesser expressed in peripheral blood leukocytes, small intestine and ovary and lung.
Molecular Function
actin binding; C-C chemokin binding; GPCR; Receptor; Transducer; Host-virus interaction
Structure
Interacts with PRAF2, HIV-1 surface protein gp120. Glycosylation on Ser-6 is required for binding with CCL4.
Subcellular Location
Cell membrane; Mulipass membrane protein.
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-CCR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCR5 antibody
Affinity Purified Chemokine receptor type 5 Antibody
Receptor for several inflammatory C-C chemokines. May play a role in control of granulocytic lineage proliferation or differentiation.
Applications Tested/Suitable for anti-CCR5 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CCR5 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Western Blot (WB) of anti-CCR5 antibody
anti-CCR5 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CCR5 antibody
anti-CCR5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CCR5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,524 Da
NCBI Official Full Name
CCR5 receptor, partial
NCBI Official Synonym Full Names
C-C motif chemokine receptor 5 (gene/pseudogene)
NCBI Official Symbol
NCBI Official Synonym Symbols
CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
  [Similar Products]
NCBI Protein Information
C-C chemokine receptor type 5
UniProt Protein Name
C-C chemokine receptor type 5
UniProt Synonym Protein Names
CHEMR13; HIV-1 fusion coreceptor; CD_antigen: CD195
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5  [Similar Products]
UniProt Entry Name
CCR5_HUMAN
NCBI Summary for CCR5
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Comments for CCR5
CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection

Protein type: GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell surface; cytoplasm; endosome; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity; phosphoinositide phospholipase C activity; protein binding; viral receptor activity

Biological Process: calcium ion transport; calcium-mediated signaling; cell surface receptor linked signal transduction; cell-cell signaling; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; entry into host cell; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; MAPKKK cascade; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; viral envelope fusion with host membrane

Disease: Diabetes Mellitus, Insulin-dependent, 22; Hepatitis C Virus, Susceptibility To; West Nile Virus, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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