• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-A2ML1 antibody :: Rabbit anti-Human, mouse A2ML1 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS9209002
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

A2ML1, Polyclonal Antibody

Also Known As

A2ML1 Antibody (N-term)

Product Synonym Names
Alpha-2-macroglobulin-like protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9; A2ML1 {ECO:0000312|EMBL:AAI121321}
Antibody/Peptide Pairs
A2ML1 peptide (MBS9225342) is used for blocking the activity of A2ML1 antibody (MBS9209002)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
345-373
Immunogen Sequence Length
963
OMIM
610627
3D Structure
ModBase 3D Structure for A8K2U0
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This A2ML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-373 amino acids from the N-terminal region of human A2ML1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-A2ML1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-A2ML1 antibody
A2ML1 is a new member of the alpha 2-macroglobulin protease inhibitor family, and shares most the characteristics of this family. It is the first family member detected in the epidermis and may play an important role during desquamation by inhibiting extracellular proteases.
Product Categories/Family for anti-A2ML1 antibody
Applications Tested/Suitable for anti-A2ML1 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-A2ML1 antibody
WB~~1:1000

Western Blot (WB) of anti-A2ML1 antibody
Western blot analysis of A2ML1 Antibody (N-term) in mouse lung tissue lysates (35ug/lane). A2ML1 (arrow) was detected using the purified Pab.
anti-A2ML1 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-A2ML1 antibody
A2ML1 Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-A2ML1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for A2ML1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
161107
NCBI Official Full Name
alpha-2-macroglobulin-like protein 1 isoform 2
NCBI Official Synonym Full Names
alpha-2-macroglobulin-like 1
NCBI Official Symbol
A2ML1  [Similar Products]
NCBI Official Synonym Symbols
CPAMD9
  [Similar Products]
NCBI Protein Information
alpha-2-macroglobulin-like protein 1
UniProt Protein Name
Alpha-2-macroglobulin-like protein 1
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9
UniProt Gene Name
A2ML1  [Similar Products]
UniProt Entry Name
A2ML1_HUMAN
NCBI Summary for A2ML1
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Comments for A2ML1
A2ML1: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity

Biological Process: regulation of endopeptidase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-A2ML1 antibody
 Reference Product  PubMed Publications
 KLK7 antibody  >2 publications with A2ML1 and KLK7
Diseases associated with anti-A2ML1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with A2ML1 and Inflammation
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000