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anti-AATF antibody :: Rabbit anti-Human, Mouse AATF Polyclonal Antibody

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Catalog # MBS150631
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

AATF, Polyclonal Antibody

Also Known As

AATF Antibody

Product Synonym Names
DED; BFR2; CHE1; CHE-1; DED; HSPC277; Protein AATF; Apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor
Antibody/Peptide Pairs
AATF peptide (MBS152971) is used for blocking the activity of AATF antibody (MBS150631)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3D Structure
ModBase 3D Structure for Q9NY61
Species Reactivity
Human, Mouse
AATF Antibody is immunoaffinity purified IgG.
1 mg/mL (lot specific)
AATF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human AATF.
AATF Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
AATF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-AATF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AATF antibody
AATF Antibody: AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
Applications Tested/Suitable for anti-AATF antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AATF antibody
AATF antibody can be used for the detection of AATF by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-AATF antibody
Western blot analysis of AATF in human small intestine cell lysate with AATF antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-AATF antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AATF antibody
Immunohistochemistry of AATF in human small intestine tissue with AATF antibody at 10 μg/mL.
anti-AATF antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-AATF antibody
Immunofluorescence of AATF in Human Small Intestine cells with AATF antibody at 20 μg/mL.
anti-AATF antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for AATF. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,133 Da
NCBI Official Full Name
protein AATF
NCBI Official Synonym Full Names
apoptosis antagonizing transcription factor
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor
UniProt Protein Name
Protein AATF
UniProt Synonym Protein Names
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CHE1; DED  [Similar Products]
UniProt Entry Name
NCBI Summary for AATF
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
UniProt Comments for AATF
AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.

Protein type: RNA-binding; Nucleolus; Transcription factor

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: Golgi apparatus; centrosome; focal adhesion; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; leucine zipper domain binding; transcription factor activity; tau protein binding

Biological Process: nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of amyloid precursor protein biosynthetic process; regulation of mitotic cell cycle; ribosome biogenesis and assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of superoxide release; cell adhesion; response to DNA damage stimulus; embryonic cleavage; negative regulation of apoptosis
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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