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anti-AATK antibody :: Rabbit anti-Human, mouse AATK Polyclonal Antibody

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Catalog # MBS9206001
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

AATK, Polyclonal Antibody

Also Known As

AATK Antibody (N-Term)

Product Synonym Names
Serine/threonine-protein kinase LMTK1; Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP; AATK; AATYK; KIAA0641; LMR1; LMTK1
Antibody/Peptide Pairs
AATK peptide (MBS9230027) is used for blocking the activity of AATK antibody (MBS9206001)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1374
OMIM
605276
3D Structure
ModBase 3D Structure for Q6ZMQ8
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This AATK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-90 amino acids from the human AATK.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Crown Antibody
Yes
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AATK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AATK antibody
May be involved in neuronal differentiation.
Applications Tested/Suitable for anti-AATK antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AATK antibody
WB~~1:2000

Western Blot (WB) of anti-AATK antibody
All lanes : Anti-AATK Antibody (N-Term) at 1:2000 dilution
Lane 1: Hela whole cell lysates
Lane 2: NIH/3T3 whole cell lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 145 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-AATK antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AATK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
144569
NCBI Official Full Name
serine/threonine-protein kinase LMTK1 isoform 1
NCBI Official Synonym Full Names
apoptosis-associated tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77
  [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase LMTK1
UniProt Protein Name
Serine/threonine-protein kinase LMTK1
UniProt Synonym Protein Names
Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP
UniProt Gene Name
UniProt Synonym Gene Names
AATYK; KIAA0641; LMR1; LMTK1; AATYK; p35BP  [Similar Products]
UniProt Entry Name
LMTK1_HUMAN
NCBI Summary for AATK
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Comments for AATK
Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.

Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.11.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr family

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: recycling endosome; perinuclear region of cytoplasm; endoplasmic reticulum; integral to membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; ATP binding

Biological Process: neuron apoptosis; brain development; negative regulation of axon extension; Rab protein signal transduction
Product References and Citations for anti-AATK antibody
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Honma N.,et al.Biochem. Biophys. Res. Commun. 310:398-404(2003).
Raghunath M.,et al.Brain Res. Mol. Brain Res. 77:151-162(2000).

Research Articles on AATK
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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