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anti-ABCB4 antibody :: Rabbit anti-Human, Mouse ABCB4 Polyclonal Antibody

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Catalog # MBS648773
Unit / Price
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  0.2 mL  /  $610 +1 FREE 8GB USB
anti-ABCB4 antibody
Product Name

ABCB4, Polyclonal Antibody

Full Product Name

ABCB4, ID (ABCB4, MDR3, PGY3, Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3)

Product Synonym Names
Anti -ABCB4, ID (ABCB4, MDR3, PGY3, Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (87031361..87105019, complement). Location: 7q21.1
OMIM
171060
3D Structure
ModBase 3D Structure for P21439
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Human, mouse
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632~661 amino acids from the central region of human ABCB4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ABCB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCB4 antibody
The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
Applications Tested/Suitable for anti-ABCB4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ABCB4 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
141,523 Da[Similar Products]
NCBI Official Full Name
ABCB4 protein
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
NCBI Official Symbol
ABCB4  [Similar Products]
NCBI Official Synonym Symbols
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
  [Similar Products]
NCBI Protein Information
multidrug resistance protein 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3
UniProt Protein Name
Multidrug resistance protein 3
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4; P-glycoprotein 3
Protein Family
UniProt Gene Name
ABCB4  [Similar Products]
UniProt Synonym Gene Names
MDR3; PGY3  [Similar Products]
UniProt Entry Name
MDR3_HUMAN
NCBI Summary for ABCB4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB4
Function: Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

Catalytic activity: ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subunit structure: Interacts with HAX1

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Involvement in disease: Cholestasis, progressive familial intrahepatic, 3 (PFIC3) [MIM:602347]: A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11 Ref.13Cholestasis of pregnancy, intrahepatic 3 (ICP3) [MIM:614972]: A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. It causes fetal distress, spontaneous premature delivery and intrauterine death. Patients have spontaneous and progressive disappearance of cholestasis after delivery. Cholestasis results from abnormal biliary transport from the liver into the small intestine.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.15 Ref.16Gallbladder disease 1 (GBD1) [MIM:600803]: One of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.14

Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains.

Sequence caution: The sequence CAA84542.1 differs from that shown. Reason: Probable cloning artifact.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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