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anti-ABCC9 antibody :: Rabbit anti-Human, mouse ABCC9 Polyclonal Antibody

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Catalog # MBS9211663
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABCC9, Polyclonal Antibody

Also Known As

ABCC9 Antibody (Center)

Product Synonym Names
ATP-binding cassette sub-family C member 9; Sulfonylurea receptor 2; ABCC9; SUR2
Antibody/Peptide Pairs
ABCC9 peptide (MBS9223375) is used for blocking the activity of ABCC9 antibody (MBS9211663)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
640-669
Immunogen Sequence Length
1549
OMIM
239850
3D Structure
ModBase 3D Structure for O60706
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This ABCC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-669 amino acids from the Central region of human ABCC9.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.488 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCC9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC9 antibody
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the MRP subfamily which is involved in
multi-drug resistance. This protein is thought to form
ATP-sensitive potassium channels in cardiac, skeletal, and vascular
and non-vascular smooth muscle. Protein structure suggests a role
as the drug-binding channel-modulating subunit of the
extrapancreatic ATP-sensitive potassium channels. No disease has
been associated with this gene thus far. Alternative splicing of
this gene results in several products, two of which result from
differential usage of two terminal exons and one of which results
from exon deletion.
Applications Tested/Suitable for anti-ABCC9 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCC9 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCC9 antibody
ABCC9 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ABCC9 Antibody detected the ABCC9 protein (arrow).
anti-ABCC9 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCC9. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
174223
NCBI Official Full Name
ATP-binding cassette sub-family C member 9 isoform SUR2A
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
NCBI Official Symbol
ABCC9  [Similar Products]
NCBI Official Synonym Symbols
SUR2; ABC37; CANTU; CMD1O; ATFB12
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family C member 9
UniProt Protein Name
ATP-binding cassette sub-family C member 9
UniProt Synonym Protein Names
Sulfonylurea receptor 2
Protein Family
UniProt Gene Name
ABCC9  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ABCC9_HUMAN
NCBI Summary for ABCC9
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
UniProt Comments for ABCC9
ABCC9: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O); also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12). ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Defects in ABCC9 are the cause of hypertrichotic osteochondrodysplasia (HTOCD). A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: voltage-gated potassium channel complex; sarcomere; ATP-sensitive potassium channel complex; plasma membrane; sarcolemma

Molecular Function: potassium channel regulator activity; potassium channel activity; ATPase activity, coupled to transmembrane movement of substances; sulfonylurea receptor activity; transporter activity; ATP binding

Biological Process: synaptic transmission; potassium ion import; metabolic process; signal transduction; transmembrane transport; defense response to virus; potassium ion transport

Disease: Cantu Syndrome; Cardiomyopathy, Dilated, 1o; Atrial Fibrillation, Familial, 12
Product References and Citations for anti-ABCC9 antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Kim, S.J., et al. Biochem. Biophys. Res. Commun. 391(1):974-978(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Disclaimer
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