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anti-ABCG1 antibody :: Rabbit anti-Human, mouse ABCG1 Polyclonal Antibody

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Catalog # MBS9203184
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABCG1, Polyclonal Antibody

Also Known As

ABCG1 Antibody (N-term)

Product Synonym Names
ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog; ABCG1; ABC8; WHT1
Antibody/Peptide Pairs
ABCG1 peptide (MBS9226132) is used for blocking the activity of ABCG1 antibody (MBS9203184)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
168-195
Immunogen Sequence Length
785
OMIM
603076
3D Structure
ModBase 3D Structure for P45844
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the N-terminal region of human ABCG1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCG1 antibody
ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types.
Applications Tested/Suitable for anti-ABCG1 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ABCG1 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCG1 antibody
Western blot analysis of ABCG1 antibody (N-term) in mouse spleen tissue lysates (35ug/lane). ABCG1 (arrow) was detected using the purified Pab.
anti-ABCG1 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-ABCG1 antibody
ABCG1 Antibody (N-term) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ABCG1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Immunohistochemistry (IHC) of anti-ABCG1 antibody
ABCG1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCG1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ABCG1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ABCG1 antibody
Confocal immunofluorescent analysis of ABCG1 Antibody (N-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-ABCG1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ABCG1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75592
NCBI Official Full Name
ATP-binding cassette sub-family G member 1 isoform 4
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family G (WHITE), member 1
NCBI Official Symbol
ABCG1  [Similar Products]
NCBI Official Synonym Symbols
ABC8; WHITE1
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family G member 1
UniProt Protein Name
ATP-binding cassette sub-family G member 1
UniProt Synonym Protein Names
ATP-binding cassette transporter 8; White protein homolog
Protein Family
UniProt Gene Name
ABCG1  [Similar Products]
UniProt Synonym Gene Names
ABC8; WHT1  [Similar Products]
UniProt Entry Name
ABCG1_HUMAN
NCBI Summary for ABCG1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCG1
ABCG1: Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; recycling endosome; mitochondrion; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; endosome; external side of plasma membrane

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; phospholipid transporter activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; toxin transporter activity; phospholipid binding; sterol-transporting ATPase activity; ADP binding; ATP binding

Biological Process: cholesterol metabolic process; response to high density lipoprotein stimulus; detection of hormone stimulus; positive regulation of cholesterol biosynthetic process; lipoprotein metabolic process; intracellular cholesterol transport; cholesterol efflux; response to lipid; response to organic substance; amyloid precursor protein catabolic process; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; regulation of transcription, DNA-dependent; transmembrane transport; phospholipid homeostasis
Product References and Citations for anti-ABCG1 antibody
Furuyama,S., J. Atheroscler. Thromb. 16 (3), 194-200 (2009)
Stefulj,J., Circ. Res. 104 (5), 600-608 (2009)
Mauerer,R., Exp. Mol. Med. 41 (2), 126-132 (2009)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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