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anti-ABI2 antibody :: Rabbit anti-Human, mouse ABI2 Polyclonal Antibody

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Catalog # MBS9201003
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABI2, Polyclonal Antibody

Also Known As

ABI2 Antibody (N-term)

Product Synonym Names
Abl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1; ABI2; ARGBPIA
Antibody/Peptide Pairs
ABI2 peptide (MBS9219232) is used for blocking the activity of ABI2 antibody (MBS9201003)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
1-30
Immunogen Sequence Length
475
OMIM
606442
3D Structure
ModBase 3D Structure for Q9NYB9
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This ABI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ABI2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABI2 antibody
ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May be involved in cytoskeletal reorganization. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Product Categories/Family for anti-ABI2 antibody
Applications Tested/Suitable for anti-ABI2 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-ABI2 antibody
WB~~1:1000

Western Blot (WB) of anti-ABI2 antibody
ABI2 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ABI2 antibody detected the ABI2 protein (arrow).
anti-ABI2 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-ABI2 antibody
ABI2 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ABI2 antibody detected the ABI2 protein (arrow).
anti-ABI2 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-ABI2 antibody
ABI2 Antibody (N-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
anti-ABI2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for ABI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55663
NCBI Official Full Name
abl interactor 2 isoform c
NCBI Official Synonym Full Names
abl-interactor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB
  [Similar Products]
NCBI Protein Information
abl interactor 2
UniProt Protein Name
Abl interactor 2
UniProt Synonym Protein Names
Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ARGBPIA; Abi-2; AblBP3; ArgBP1  [Similar Products]
UniProt Entry Name
ABI2_HUMAN
UniProt Comments for ABI2
Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoskeleton; lamellipodium; cytoplasm; cytosol; filopodium

Molecular Function: protein binding; DNA binding; ubiquitin protein ligase binding; protein complex binding; Rac GTPase binding; cytoskeletal adaptor activity; kinase binding; SH3 domain binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; Rac protein signal transduction; cytoskeleton organization and biogenesis; cell motility
Product References and Citations for anti-ABI2 antibody
Ryu, J.R., et al. Mol. Cell. Biol. 29(7):1735-1748(2009)
Kano, S., et al. Cancer Res. 68(14):5572-5580(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Li, Y., et al. J. Cell. Sci. 120 (PT 8), 1436-1446 (2007) :
O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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