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anti-TNIP3 antibody :: Rabbit anti-Human, Mouse ABIN3 Polyclonal Antibody

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Catalog # MBS151164
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ABIN3 (TNIP3), Polyclonal Antibody

Also Known As

ABIN3 Antibody

Product Synonym Names
LIND; ABIN-3; ABIN3; LIND; TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; TNFAIP3 interacting protein 3
Antibody/Peptide Pairs
ABIN3 peptide (MBS152909) is used for blocking the activity of ABIN3 antibody (MBS151164)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
325
OMIM
608019
3D Structure
ModBase 3D Structure for Q96KP6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
ABIN3 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ABIN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3.
Buffer
ABIN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ABIN3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-TNIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNIP3 antibody
ABIN3 Antibody: The nuclear factor NF-κB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-κB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-κB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-κB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-κB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-κB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.
Applications Tested/Suitable for anti-TNIP3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TNIP3 antibody
ABIN3 antibody can be used for detection of ABIN3 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-TNIP3 antibody
Western blot analysis of ABIN3 in human spleen tissue lysate with ABIN3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-TNIP3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TNIP3 antibody
Immunohistochemistry of ABIN3 in mouse spleen tissue with ABIN3 antibody at 5 μg/mL.
anti-TNIP3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TNIP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,886 Da
NCBI Official Full Name
TNFAIP3-interacting protein 3 isoform 1
NCBI Official Synonym Full Names
TNFAIP3 interacting protein 3
NCBI Official Symbol
TNIP3  [Similar Products]
NCBI Official Synonym Symbols
LIND; ABIN-3
  [Similar Products]
NCBI Protein Information
TNFAIP3-interacting protein 3; TNIP3 beta; ABIN-3 beta; Listeria induced; listeria-induced gene protein; TNFAIP3-interacting protein 3 beta; A20-binding inhibitor of NF-kappa-B activation 3
UniProt Protein Name
TNFAIP3-interacting protein 3
UniProt Synonym Protein Names
A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein
UniProt Gene Name
TNIP3  [Similar Products]
UniProt Synonym Gene Names
ABIN-3  [Similar Products]
UniProt Entry Name
TNIP3_HUMAN
UniProt Comments for TNIP3
TNIP3: Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 4q27

Molecular Function: polyubiquitin binding

Biological Process: MyD88-independent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; toll-like receptor 4 signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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