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anti-ACAP1 antibody :: Rabbit anti-Human, mouse ACAP1 Polyclonal Antibody

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Catalog # MBS9210644
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ACAP1, Polyclonal Antibody

Also Known As

ACAP1 Antibody (N-term)

Product Synonym Names
Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1; ACAP1; CENTB1; KIAA0050
Antibody/Peptide Pairs
ACAP1 peptide (MBS9218170) is used for blocking the activity of ACAP1 antibody (MBS9210644)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
96-125
Immunogen Sequence Length
740
OMIM
607763
3D Structure
ModBase 3D Structure for Q15027
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This ACAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the N-terminal region of human ACAP1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ACAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACAP1 antibody
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
Product Categories/Family for anti-ACAP1 antibody
Applications Tested/Suitable for anti-ACAP1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ACAP1 antibody
WB~~1:1000

Western Blot (WB) of anti-ACAP1 antibody
ACAP1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ACAP1 antibody detected the ACAP1 protein (arrow).
anti-ACAP1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-ACAP1 antibody
ACAP1 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the ACAP1 antibody detected the ACAP1 protein (arrow).
anti-ACAP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ACAP1 antibody
ACAP1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACAP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ACAP1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ACAP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81536
NCBI Official Full Name
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
NCBI Official Synonym Full Names
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
NCBI Official Symbol
ACAP1  [Similar Products]
NCBI Official Synonym Symbols
CENTB1
  [Similar Products]
NCBI Protein Information
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Protein Name
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Synonym Protein Names
Centaurin-beta-1; Cnt-b1
UniProt Gene Name
ACAP1  [Similar Products]
UniProt Synonym Gene Names
CENTB1; KIAA0050; Cnt-b1  [Similar Products]
UniProt Entry Name
ACAP1_HUMAN
UniProt Comments for ACAP1
CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; recycling endosome membrane

Molecular Function: zinc ion binding

Biological Process: protein transport; positive regulation of GTPase activity
Product References and Citations for anti-ACAP1 antibody
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cuthbert, E.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C263-C270 (2008) :
Li, J., et al. J. Cell Biol. 178(3):453-464(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Shinozaki-Narikawa, N., et al. Traffic 7(11):1539-1550(2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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